Journal article
Frontostriatal circuits and the development of bulimia nervosa
Frontiers in behavioral neuroscience, v 8, pp 395-395
17 Nov 2014
PMID: 25452718
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Bulimia nervosa (BN) is characterized by both recurrent episodes of binge eating that are, in part, defined by a sense of loss of control and compensatory behaviors to avoid weight gain. Impulsive behaviors are also common in individuals with BN, indicating more pervasive difficulties in behavioral self-regulation. Findings from functional and anatomical neuroimaging studies of individuals with BN suggest dysfunction in the dorsal frontostriatal circuits that support self-regulatory capacities and habit learning and in overlapping ventral circuits that support reward processing and reward-based learning. In this review, we describe the normal development of frontostriatal circuits and then present behavioral and neuroimaging data from adolescents and adults with BN. These data suggest that the abnormal maturation of frontostriatal circuits may contribute to the habitual binge-eating and purging behaviors of BN. Future longitudinal imaging studies will improve understanding of how these circuits contribute to the developmental trajectory of BN and will inform novel interventions that could target or prevent the impulsive and habit-like features of this disorder.
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Details
- Title
- Frontostriatal circuits and the development of bulimia nervosa
- Creators
- Laura A. Berner - Drexel UniversityRachel Marsh - Columbia University
- Publication Details
- Frontiers in behavioral neuroscience, v 8, pp 395-395
- Publisher
- Frontiers Media Sa
- Number of pages
- 12
- Grant note
- NARSAD 5F31MH097406; 5K01MH077652; 3K01MH077652-04S1; 1R01MH090062-01A1 / NIMH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) Sackler Institute of Developmental Psychobiology F31MH097406 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH)
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000347926200001
- Scopus ID
- 2-s2.0-84979900468
- Other Identifier
- 991019319080004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Behavioral Sciences
- Neurosciences