Journal article
Fructose promotes liver cancer via microbial acetate-induced O-GlcNAcylation
Trends in endocrinology and metabolism
13 Dec 2023
PMID: 38097465
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
High dietary fructose consumption is linked to multiple disease states, including cancer. Zhou and colleagues recently reported a novel mechanism where high dietary fructose levels increase acetate production by the gut microbiome increasing post-translational modification O-GlcNAcylation in liver cells, which contributes to disease progression in mouse models of hepatocellular carcinoma.
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Details
- Title
- Fructose promotes liver cancer via microbial acetate-induced O-GlcNAcylation
- Creators
- Emily M Esquea - Drexel UniversityRiley G Young - Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA, USAMauricio J Reginato - Drexel University
- Publication Details
- Trends in endocrinology and metabolism
- Publisher
- Elsevier
- Grant note
- U01 CA244303 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:001184986300001
- Scopus ID
- 2-s2.0-85179801558
- Other Identifier
- 991021811638404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Endocrinology & Metabolism