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Journal article
Fucosylated glycoproteins as markers of liver disease
Disease markers, v 25(4-5), pp 259-265
01 Jan 2008
PMID: 19126969
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Changes in N-linked glycosylation are known to occur during the development of various diseases. For example, increased branching of oligosaccharides has been associated with cancer metastasis and has been correlated to tumor progression in human cancers of the breast, colon and melanomas. Increases in core fucosylation have also been associated with the development of hepatocellular carcinoma (HCC). Recently, changes in both the total serum glycome and the glycosylation of specific IgG molecules have been observed in people with liver fibrosis and cirrhosis. The mechanisms by which changes in glycosylation are observed and their use as biomarkers of disease will be discussed.
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Details
- Title
- Fucosylated glycoproteins as markers of liver disease
- Creators
- Anand Mehta - Drexel UniversityTimothy M. Block - Drexel University
- Publication Details
- Disease markers, v 25(4-5), pp 259-265
- Publisher
- Hindawi Publishing Group
- Number of pages
- 7
- Grant note
- Commonwealth of Pennsylvania Hepatitis B Foundation R01CA120206 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) UO1 CA084951-06; R01 CA120206-01 / National Cancer Institute (NCI); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000263028900007
- Scopus ID
- 2-s2.0-58149400525
- Other Identifier
- 991019167527204721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biotechnology & Applied Microbiology
- Genetics & Heredity
- Medicine, Research & Experimental
- Pathology