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Journal article
Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer
BMC biology, v 17(1), pp 52-52
04 Jul 2019
PMCID: PMC6610925
PMID: 31272438
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Altered metabolism and deregulated cellular energetics are now considered a hallmark of all cancers. Glucose, glutamine, fatty acids, and amino acids are the primary drivers of tumor growth and act as substrates for the hexosamine biosynthetic pathway (HBP). The HBP culminates in the production of an amino sugar uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) that, along with other charged nucleotide sugars, serves as the basis for biosynthesis of glycoproteins and other glycoconjugates. These nutrient-driven post-translational modifications are highly altered in cancer and regulate protein functions in various cancer-associated processes. In this review, we discuss recent progress in understanding the mechanistic relationship between the HBP and cancer.
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Details
- Title
- Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer
- Creators
- Neha M. Akella - Drexel UniversityLorela Ciraku - Drexel UniversityMauricio J. Reginato - Drexel University
- Publication Details
- BMC biology, v 17(1), pp 52-52
- Publisher
- BioMed Central
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000474350600002
- Scopus ID
- 2-s2.0-85068549324
- Other Identifier
- 991019168424904721
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