Full-field strain mapping of healthy and pathological mouse aortas using stereo digital image correlation

Brooks A. Lane; Ricardo J. Cardoza; Susan M. Lessner; Narendra R. Vyavahare; Michael A. Sutton; John F. Eberth

doi:10.1016/j.jmbbm.2023.105745

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Full-field strain mapping of healthy and pathological mouse aortas using stereo digital image correlation

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Full-field strain mapping of healthy and pathological mouse aortas using stereo digital image correlation

Brooks A. Lane, Ricardo J. Cardoza, Susan M. Lessner, Narendra R. Vyavahare, Michael A. Sutton and John F. Eberth

Journal of the mechanical behavior of biomedical materials, v 141, 105745

01 May 2023

DOI: https://doi.org/10.1016/j.jmbbm.2023.105745

PMID: 36893686

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https://pmc.ncbi.nlm.nih.gov/articles/PMC10081968/pdf/nihms-1881328.pdfView

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Abstract

Arterial biomechanics

DIC

Mouse aortopathy

Stereo imaging

Strain map

The murine aorta is a complex, heterogeneous structure that undergoes large and sometimes asymmetrical deformations under loading. For analytical convenience, mechanical behavior is predominantly described using global quantities that fail to capture critical local information essential to elucidating aortopathic processes. Here, in our methodological study, we used stereo digital image correlation (StereoDIC) to measure the strain profiles of speckle-patterned healthy and elastase-infused, pathological mouse aortas submerged in a temperature-controlled liquid medium. Our unique device rotates two 15-degree stereo-angle cameras that gather sequential digital images while simultaneously performing conventional biaxial pressure-diameter and force-length testing. A StereoDIC Variable Ray Origin (VRO) camera system model is employed to correct for high-magnification image refraction through hydrating physiological media. The resultant Green-Lagrange surface strain tensor was quantified at different blood vessel inflation pressures, axial extension ratios, and after aneurysm-initiating elastase exposure. Quantified results capture large, heterogeneous, inflation-related, circumferential strains that are drastically reduced in elastase-infused tissues. Shear strains, however, were very small on the tissue’s surface. Spatially averaged StereoDIC-based strains were generally more detailed than those determined using conventional edge detection techniques.

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Title: Full-field strain mapping of healthy and pathological mouse aortas using stereo digital image correlation
Creators: Brooks A. Lane - Drexel University, School of Biomedical Engineering, Science, and Health Systems
Ricardo J. Cardoza - University of Pittsburgh
Susan M. Lessner - University of South Carolina
Narendra R. Vyavahare - Clemson University
Michael A. Sutton - University of South Carolina
John F. Eberth - Drexel University, School of Biomedical Engineering, Science, and Health Systems
Publication Details: Journal of the mechanical behavior of biomedical materials, v 141, 105745
Publisher: Elsevier
Resource Type: Journal article
Language: English
Academic Unit: School of Biomedical Engineering, Science, and Health Systems
Web of Science ID: WOS:000951425500001
Scopus ID: 2-s2.0-85149623149
Other Identifier: 991021860733004721

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Collaboration types: Domestic collaboration
Web of Science research areas: Engineering, Biomedical; Materials Science, Biomaterials

Full-field strain mapping of healthy and pathological mouse aortas using stereo digital image correlation

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