Journal article
Fumonisin B1 and risk of hepatocellular carcinoma in two Chinese cohorts
Food and chemical toxicology, v 50(03-04), pp 679-683
Mar 2012
PMID: 22142693
Abstract
► Fumonisin B1 (FB1) causes hepatocellular cancer (HCC) in animal models. ► FB1 has a short half-life, therefore FB1 levels were measured in toenails using HPLC. ► The association between FB1 and HCC was studied in a meta-analysis of two cohorts. ► FB1 was not associated with HCC in either study or the pooled meta-analysis.
Fumonisin B1 (FB1), a mycotoxin that contaminates corn in certain climates, has been demonstrated to cause hepatocellular cancer (HCC) in animal models. Whether a relationship between FB1 and HCC exists in humans is not known. To examine the hypothesis, we conducted case-control studies nested within two large cohorts in China; the Haimen City Cohort and the General Population Study of the Nutritional Intervention Trials cohort in Linxian. In the Haimen City Cohort, nail FB1 levels were determined in 271 HCC cases and 280 controls. In the General Population Nutritional Intervention Trial, nail FB1 levels were determined in 72 HCC cases and 147 controls. In each population, odds ratios and 95% confidence intervals (95%CI) from logistic regression models estimated the association between measurable FB1 and HCC, adjusting for hepatitis B virus infection and other factors. A meta-analysis that included both populations was also conducted. The analysis revealed no statistically significant association between FB1 and HCC in either Haimen City (OR=1.10, 95%CI=0.64–1.89) or in Linxian (OR=1.47, 95%CI=0.70–3.07). Similarly, the pooled meta-analysis showed no statistically significant association between FB1 exposure and HCC (OR=1.22, 95%CI=0.79–1.89). These findings, although somewhat preliminary, do not support an associated between FB1 and HCC.
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Details
- Title
- Fumonisin B1 and risk of hepatocellular carcinoma in two Chinese cohorts
- Creators
- E Christina Persson - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USAVikash Sewram - Oncology Research Unit, Medical Research Council, Durban, South AfricaAlison A Evans - Drexel University School of Public Health, Philadelphia, PA, USAW Thomas London - Fox Chase Cancer Center, Philadelphia, PA, USAYvette Volkwyn - PROMEC Unit, Medical Research Council, Tygerberg, South AfricaYen-Ju Shen - Oncology Research Unit, Medical Research Council, Durban, South AfricaJacobus A Van Zyl - Indigenous Knowledge Systems Research Unit, Medical Research Council, Cape Town, South AfricaGang Chen - Hepatitis B Foundation, Doylestown, PA, USAWenyao Lin - Haimen City Center for Disease Control, Haimen City, People’s Republic of ChinaGordon S Shephard - PROMEC Unit, Medical Research Council, Tygerberg, South AfricaPhilip R Taylor - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USAJin-Hu Fan - Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Beijing, People’s Republic of ChinaSanford M Dawsey - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USAYou-Lin Qiao - Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Beijing, People’s Republic of ChinaKatherine A McGlynn - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USAChristian C Abnet - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
- Publication Details
- Food and chemical toxicology, v 50(03-04), pp 679-683
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000303284600035
- Scopus ID
- 2-s2.0-84862788688
- Other Identifier
- 991014878169004721
InCites Highlights
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Food Science & Technology
- Toxicology