Journal article
Functional Anchoring of the cAMP-Dependent Protein Kinase
Trends in cardiovascular medicine, v 8(2), pp 89-95
01 Feb 1998
PMID: 21235917
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The precision of cAMP-responsive events is controlled in part through compartmentalization of the signal transduction machinery. Recent evidence suggests that the cAMP-dependent protein kinase (PKA) is localized to specific subcellular compartments through association with A K
inase A
nchoring P
roteins (AKAPs). The AKAPs now represent a functionally related family of regulatory proteins that contain a conserved PKA binding domain and unique targeting sequences that direct the PKA-AKAP complex to subcellular structures. In this review, the recent evidence suggesting that AKAPs facilitate PKA anchoring close to key membrane substrates, such as glutamate receptors, calcium-activated potassium channels, and skeletal or cardiac muscle calcium channels, is surveyed.
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Details
- Title
- Functional Anchoring of the cAMP-Dependent Protein Kinase
- Creators
- Brian J Murphy - University of WashingtonJohn D Scott - Vollum Institute
- Publication Details
- Trends in cardiovascular medicine, v 8(2), pp 89-95
- Publisher
- Elsevier
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000072327000006
- Scopus ID
- 2-s2.0-0031930322
- Other Identifier
- 991021903117304721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems