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Functional Coupling between Neurons and Glia
Journal article   Open access   Peer reviewed

Functional Coupling between Neurons and Glia

Veronica Alvarez-Maubecin, Fernando García-Hernández, John T. Williams and Elisabeth J. Van Bockstaele
The Journal of neuroscience, v 20(11), pp 4091-4098
01 Jun 2000
DOI: https://doi.org/10.1523/JNEUROSCI.20-11-04091.2000
PMID: 10818144
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1523/JNEUROSCI.20-11-04091.2000View
Published, Version of Record (VoR) Open

Abstract

ARTICLE
Neuronal–glial interactions play an important role in information processing in the CNS. Previous studies have indicated that electrotonic coupling between locus ceruleus (LC) neurons is involved in synchronizing the spontaneous activity. The results of the present study extend the functional electrotonic coupling to interactions between neurons and glia. Spontaneous oscillations in the membrane potential were observed in a subset of glia. These oscillations were synchronous with the firing of neurons, insensitive to transmitter receptor antagonists and disrupted by carbenoxolone, a gap junction blocker. Hyperpolarization of neurons with [Met] 5 enkephalin blocked the oscillations in glia. Selective depolarization of glia with a glutamate transporter substrate ( l -α-aminoadipic acid) increased the neuronal firing rate, suggesting that changes in the membrane potential of glia can modulate neuronal excitability through heterocellular coupling. Dye-coupling experiments further confirmed that small molecules could be transferred through gap junctions between these distinct cell types. No dye transfer was observed between neurons and oligodendrocytes or between astrocytes and oligodendrocytes, suggesting that the junctional communication was specific for astrocytes and neurons. Finally, immunoelectron microscopy studies established that connexins, the proteins that form gap junctions, were present on portions of the plasmalemma, bridging the cytoplasm of neurons and glia in LC. This heterocellular coupling extends the mechanisms by which glia participate in the network properties of the LC in which the degree of coupling is thought to influence cognitive performance.

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Collaboration types
Domestic collaboration
Web of Science research areas
Neurosciences
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