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Functional MRI, resting state fMRI, and DTI for predicting verbal fluency outcome following resective surgery for temporal lobe epilepsy
Journal article   Open access   Peer reviewed

Functional MRI, resting state fMRI, and DTI for predicting verbal fluency outcome following resective surgery for temporal lobe epilepsy

Karol Osipowicz, Michael R Sperling, Ashwini D Sharan and Joseph I Tracy
Journal of neurosurgery, v 124(4), pp 929-937
Apr 2016
DOI: https://doi.org/10.3171/2014.9.JNS131422
PMID: 26406797
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.3171/2014.9.JNS131422View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open

Abstract

Adult Anterior Temporal Lobectomy - methods Cognition Diffusion Tensor Imaging - methods Drug Resistant Epilepsy - surgery Epilepsy, Temporal Lobe - psychology Epilepsy, Temporal Lobe - surgery Female Humans Magnetic Resonance Imaging - methods Male Middle Aged Multimodal Imaging - methods Neuropsychological Tests Neurosurgical Procedures - adverse effects Neurosurgical Procedures - methods Neurosurgical Procedures - psychology Postoperative Complications - psychology Predictive Value of Tests Rest Temporal Lobe - surgery Treatment Outcome Verbal Behavior White Matter - surgery
Predicting cognitive function following resective surgery remains an important clinical goal. Each MRI neuroimaging technique can potentially provide unique and distinct insight into changes that occur in the structural or functional organization of "at-risk" cognitive functions. The authors tested for the singular and combined power of 3 imaging techniques (functional MRI [fMRI], resting state fMRI, diffusion tensor imaging) to predict cognitive outcome following left (dominant) anterior temporal lobectomy for intractable epilepsy. METHODS; The authors calculated the degree of deviation from normal, determined the rate of change in this measure across the pre- and postsurgical imaging sessions, and then compared these measures for their ability to predict verbal fluency changes following surgery. The data show that the 3 neuroimaging techniques, in a combined model, can reliably predict cognitive outcome following anterior temporal lobectomy for medically intractable temporal lobe epilepsy. These findings suggest that these 3 imaging modalities can be used effectively, in an additive fashion, to predict functional reorganization and cognitive outcome following anterior temporal lobectomy.

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44 citations in Web of Science
45 citations in Scopus

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Collaboration types
Domestic collaboration
Web of Science research areas
Clinical Neurology
Surgery
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