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Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Functional Neuroimaging in Traumatic Brain Injury: From Nodes to Networks
Frontiers in neurology, v 8, 407
24 Aug 2017
PMID: 28883806
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Since the invention of functional magnetic resonance imaging (fMRI), thousands of studies in healthy and clinical samples have enlightened our understanding of the organization of cognition in the human brain and neuroplastic changes following brain disease and injury. Increasingly, studies involve analyses rooted in complex systems theory and analysis applied to clinical samples. Given the complexity in available approaches, concise descriptions of the theoretical motivation of network techniques and their relationship to traditional approaches and theory are necessary. To this end, this review concerns the use of fMRI to understand basic cognitive function and dysfunction in the human brain scaling from emphasis on basic units (or “nodes”) in the brain to interactions within and between brain networks. First, major themes and theoretical issues in the scientific study of the injured brain are introduced to contextualize these analyses, particularly concerning functional “brain reorganization.” Then, analytic approaches ranging from the voxel level to the systems level using graph theory and related approaches are reviewed as complementary approaches to examine neurocognitive processes following TBI. Next, some major findings relevant to functional reorganization hypotheses are discussed. Finally, major open issues in functional network analyses in neurotrauma are discussed in theoretical, analytic, and translational terms.
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Details
- Title
- Functional Neuroimaging in Traumatic Brain Injury: From Nodes to Networks
- Creators
- John D. Medaglia - University of Pennsylvania
- Publication Details
- Frontiers in neurology, v 8, 407
- Publisher
- Frontiers Media S.A.
- Grant note
- Perelman School of Medicine, University of Pennsylvania 1-DP5 OD021352-01 / NIH Office of the Director Translational Neuroscience Initiative
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000408324700001
- Scopus ID
- 2-s2.0-85028417091
- Other Identifier
- 991019296541904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Neurosciences