Journal article
Functional Properties of Synaptic Transmission in Primary Sense Organs
The Journal of neuroscience, v 29(41), pp 12802-12806
14 Oct 2009
PMID: 19828792
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Sensory receptors transduce physical stimuli in the environment into neural signals that are interpreted by the brain. Although considerable attention has been given to how the sensitivity and dynamic range of sensory receptors is established, peripheral synaptic interactions improve the fidelity with which receptor output is transferred to the brain. For instance, synapses in the retina, cochlea, and primary olfactory system use mechanisms that fine-tune the responsiveness of postsynaptic neurons and the dynamics of exocytosis; these permit microcircuit interactions to encode efficiently the output of sensory receptors with the fidelity and dynamic range necessary to extract the salient features of the physical stimuli. The continuous matching of presynaptic and postsynaptic responsiveness highlight how the primary sensory organs have been optimized and can be modulated to resolve sparse sensory signals and to encode the entire range of receptor output.
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Details
- Title
- Functional Properties of Synaptic Transmission in Primary Sense Organs
- Creators
- Joshua H Singer - Departments of Ophthalmology and Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611Elisabeth Glowatzki - Department of Otolaryngology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205Tobias Moser - Department of Otolaryngology and Center for Molecular Physiology of the Brain, University of Göttingen, 37073 Göttingen, GermanyBen W Strowbridge - Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106Vikas Bhandawat - Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, andAlapakkam P Sampath - Zilkha Neurogenetic Institute, Department of Physiology and Biophysics, University of Southern California, Los Angeles, California 90089
- Publication Details
- The Journal of neuroscience, v 29(41), pp 12802-12806
- Series
- Mini-Symposium
- Publisher
- Society for Neuroscience
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000270845000013
- Scopus ID
- 2-s2.0-70350450546
- Other Identifier
- 991014877946604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences