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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Functional alignment with anatomical networks is associated with cognitive flexibility
Nature human behaviour, v 2(2), pp 156-164
01 Feb 2018
PMID: 30498789
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cognitive flexibility describes the human ability to switch between modes of mental function to achieve goals. Mental switching is accompanied by transient changes in brain activity, which must occur atop an anatomical architecture that bridges disparate cortical and subcortical regions via underlying white matter tracts. However, an integrated understanding of how white matter networks might constrain brain dynamics during cognitive processes requiring flexibility has remained elusive. Here, to address this challenge, we applied emerging tools from graph signal processing to examine whether blood oxygen level-dependent signals measured at each point in time correspond to complex underlying anatomical networks in 28 individuals performing a perceptual task that probed cognitive flexibility. We found that the alignment between functional signals and the architecture of the underlying white matter network was associated with greater cognitive flexibility across subjects. By computing a concise measure using multi-modal neuroimaging data, we uncovered an integrated structure-function relation of human behaviour.
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Details
- Title
- Functional alignment with anatomical networks is associated with cognitive flexibility
- Creators
- John D. Medaglia - Drexel UniversityWeiyu Huang - University of PennsylvaniaElisabeth A. Karuza - University of PennsylvaniaApoorva Kelkar - Drexel UniversitySharon L. Thompson-Schill - University of PennsylvaniaAlejandro Ribeiro - University of PennsylvaniaDanielle S. Bassett - University of Pennsylvania
- Publication Details
- Nature human behaviour, v 2(2), pp 156-164
- Publisher
- Springer Nature
- Number of pages
- 9
- Grant note
- W911NF-10-2-0022; W911NF-14-1-0679 / Army Research Office DP5OD021352 / OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01NS099348 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) Perelman School of Medicine R01-DC-009209-11; R01-HD-086888-01; R01-MH-107235; R01-MH107703; R01-MH-109520; R01-NS-099348; R21-MH-106799 / National Institute of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01MH107703 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) Army Research Laboratory; United States Department of Defense; US Army Research Laboratory (ARL) R01HD086888 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) Office of Naval Research BCS-1441502; CAREER PHY-1554488; BCS-1631550; CNS-1626008 / National Science Foundation; National Science Foundation (NSF) Alfred P. Sloan Foundation John D. and Catherine T. MacArthur Foundation 1-DP5-OD-021352-01 / Office of the Director at the National Institutes of Health R01DC009209 / NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Deafness & Other Communication Disorders (NIDCD)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000429375000020
- Scopus ID
- 2-s2.0-85042753812
- Other Identifier
- 991019168329004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences
- Psychology, Biological
- Psychology, Experimental