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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Functional behavior and gene expression of magnetic nanoparticle-loaded primary endothelial cells for targeting vascular stents
Nanomedicine (London, England), v 10(9), pp 1391-1406
May 2015
PMID: 25996117
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To assess functional competence and gene expression of magnetic nanoparticle (MNP)-loaded primary endothelial cells (ECs) as potential cell-based therapy vectors.
A quantitative tube formation, nitric oxide and adhesion assays were conducted to assess functional potency of the MNP-loaded ECs. A quantitative real-time PCR was used to profile genes in both MNP-loaded at static conditions and in vitro targeted ECs.
Functional behavior of MNP-loaded and unloaded cells was comparable. MNPs induce expression of genes involved in EC growth and survival, while repress genes involved in coagulation.
MNPs do not adversely affect cellular function. Gene expression indicates that targeting MNP-loaded ECs to vascular stents may potentially stimulate re-endothelialization of an implant and attenuate neointimal hyperplasia.
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Details
- Title
- Functional behavior and gene expression of magnetic nanoparticle-loaded primary endothelial cells for targeting vascular stents
- Creators
- Fatema Tuj Zohra - Drexel UniversityMikhail Medved - Drexel UniversityNina Lazareva - Drexel UniversityBoris Polyak - Drexel University
- Publication Details
- Nanomedicine (London, England), v 10(9), pp 1391-1406
- Grant note
- R01HL107771 / NHLBI NIH HHS R01 HL107771 / NHLBI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:000354879000004
- Scopus ID
- 2-s2.0-84929869666
- Other Identifier
- 991019168912804721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biotechnology & Applied Microbiology
- Nanoscience & Nanotechnology