Journal article
Functional compressive mechanics of a PVA/PVP nucleus pulposus replacement
Biomaterials, v 27(2), pp 176-184
2006
PMID: 16115678
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Emerging techniques as an alternative to the current treatments of lower back pain include nucleus replacement by an artificial material, which aims to relieve pain and restore the normal spinal motion. The compressive mechanical behavior of the PVA/PVP hydrogel nucleus implant was assessed in the present study.
PVA/PVP hydrogels were made with various PVP concentrations. The hydrogels were loaded statically under unconfined and confined conditions. Hydrogels were tested dynamically up to 10 million cycles for a compression fatigue. Also, hydrogel nucleus implants with a line-to-line fit, were implanted in the human cadaveric intervertebral discs (IVD) to determine the compressional behavior of the implanted discs.
Hydrogel samples exhibited typical non-linear response under both unconfined and confined compressions. Properties of the confinement ring dictated the observed response. Hydrogel moduli and polymer content were not different pre- and post-fatigues. Slight geometrical changes (mostly recoverable) were observed post-fatigue. In cadavers, hydrogels restored the compressive stiffness of the denucleated disc when compared with equivalent condition of the IVD.
The results of this study demonstrate that PVA/PVP hydrogels may be viable as nucleus pulposus implants. Further studies under complex loading conditions are warranted to better assess its potential as a replacement to the degenerated nucleus pulposus.
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Details
- Title
- Functional compressive mechanics of a PVA/PVP nucleus pulposus replacement
- Creators
- Abhijeet Joshi - Department of Materials Science and Engineering, Drexel University, Philadelphia, PA, USAGarland Fussell - Department of Chemical and Biological Engineering, Drexel University, Philadelphia, PA, USAJonathan Thomas - Department of Materials Science and Engineering, Drexel University, Philadelphia, PA, USAAndrew Hsuan - Department of Chemical and Biological Engineering, Drexel University, Philadelphia, PA, USAAnthony Lowman - Department of Chemical and Biological Engineering, Drexel University, Philadelphia, PA, USAAndrew Karduna - Department of Human Physiology, University of Oregon, Eugene, OR, USAEd Vresilovic - Department of Biomedical Engineering, Drexel University, Philadelphia, PA, USAMichele Marcolongo - Department of Materials Science and Engineering, Drexel University, Philadelphia, PA, USA
- Publication Details
- Biomaterials, v 27(2), pp 176-184
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000232517900005
- Scopus ID
- 2-s2.0-24644442155
- Other Identifier
- 991014877995404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials