Journal article
Functional differences of six forms of renin in rats
American journal of physiology. Renal physiology, v 254(3), pp F432-F439
Mar 1988
PMID: 3279820
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Six forms of renin with different isoelectric points (pIs) have been described in rats. This study was designed to determine if any of the renin forms have different biological activities. Each form of rat renin was semipurified and injected intravenously or intraventricularly in Sprague-Dawley rats anesthetized with pentobarbital sodium or Inactin. Changes in blood pressure (BP), renal function, sodium, and water excretion were observed, before and following equipressor doses; the peak response of BP was similar for all forms. However, the half-lives were significantly different. Form 4 (pI = 5.2) caused a significant increase in urine flow, Na, and K excretion, and urinary osmolality when given intravenously. The other forms were without significant effect. Infusion of converting enzyme inhibitor not only completely blocked the BP response, but also prevented the natriuresis and diuresis. This was observed in rats anesthetized with pentobarbital sodium or Inactin. Intraventricular infusions resulted in a diuresis and natriuresis when form 6 (pI = 4.8) was infused, but not with other forms. BP remained unchanged throughout. This study presents evidence that functional differences exist between renin forms.
Metrics
Details
- Title
- Functional differences of six forms of renin in rats
- Creators
- S. H. Kim - University of Michigan–Ann ArborM. C. Lloyd - University of Michigan–Ann ArborF. M. Sessler - University of Michigan–Ann ArborJ. Q. Feng - University of Michigan–Ann ArborR. L. Malvin - University of Michigan–Ann Arbor
- Publication Details
- American journal of physiology. Renal physiology, v 254(3), pp F432-F439
- Publisher
- AMER PHYSIOLOGICAL SOC; Rockville
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:A1988M591900068
- Scopus ID
- 2-s2.0-0023912799
- Other Identifier
- 991021899209004721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Physiology