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Functional hypergraph uncovers novel covariant structures over neurodevelopment
Journal article   Open access   Peer reviewed

Functional hypergraph uncovers novel covariant structures over neurodevelopment

Shi Gu, Muzhi Yang, John D. Medaglia, Ruben C. Gur, Raquel E. Gur, Theodore D. Satterthwaite and Danielle S. Bassett
Human brain mapping, v 38(8), pp 3823-3835
01 Aug 2017
PMID: 28493536
url
https://doi.org/10.1002/hbm.23631View
Published, Version of Record (VoR)CC BY V4.0 Open

Abstract

Life Sciences & Biomedicine Neuroimaging Neurosciences Neurosciences & Neurology Radiology, Nuclear Medicine & Medical Imaging Science & Technology
Brain development during adolescence is marked by substantial changes in brain structure and function, leading to a stable network topology in adulthood. However, most prior work has examined the data through the lens of brain areas connected to one another in large-scale functional networks. Here, we apply a recently developed hypergraph approach that treats network connections (edges) rather than brain regions as the unit of interest, allowing us to describe functional network topology from a fundamentally different perspective. Capitalizing on a sample of 780 youth imaged as part of the Philadelphia Neurodevelopmental Cohort, this hypergraph representation of resting-state functional MRI data reveals three distinct classes of subnetworks (hyperedges): clusters, bridges, and stars, which respectively represent homogeneously connected, bipartite, and focal architectures. Cluster hyperedges show a strong resemblance to previously-described functional modules of the brain including somatomotor, visual, default mode, and salience systems. In contrast, star hyperedges represent highly localized subnetworks centered on a small set of regions, and are distributed across the entire cortex. Finally, bridge hyperedges link clusters and stars in a core-periphery organization. Notably, developmental changes within hyperedges are ordered in a similar core-periphery fashion, with the greatest developmental effects occurring in networked hyperedges within the functional core. Taken together, these results reveal a novel decomposition of the network organization of human brain, and further provide a new perspective on the role of local structures that emerge across neurodevelopment. Hum Brain Mapp 38:3823-3835, 2017. (c) 2017 Wiley Periodicals, Inc.

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Web of Science research areas
Neuroimaging
Neurosciences
Radiology, Nuclear Medicine & Medical Imaging
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