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Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Functional hypergraph uncovers novel covariant structures over neurodevelopment
Human brain mapping, v 38(8), pp 3823-3835
01 Aug 2017
PMID: 28493536
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Brain development during adolescence is marked by substantial changes in brain structure and function, leading to a stable network topology in adulthood. However, most prior work has examined the data through the lens of brain areas connected to one another in large-scale functional networks. Here, we apply a recently developed hypergraph approach that treats network connections (edges) rather than brain regions as the unit of interest, allowing us to describe functional network topology from a fundamentally different perspective. Capitalizing on a sample of 780 youth imaged as part of the Philadelphia Neurodevelopmental Cohort, this hypergraph representation of resting-state functional MRI data reveals three distinct classes of subnetworks (hyperedges): clusters, bridges, and stars, which respectively represent homogeneously connected, bipartite, and focal architectures. Cluster hyperedges show a strong resemblance to previously-described functional modules of the brain including somatomotor, visual, default mode, and salience systems. In contrast, star hyperedges represent highly localized subnetworks centered on a small set of regions, and are distributed across the entire cortex. Finally, bridge hyperedges link clusters and stars in a core-periphery organization. Notably, developmental changes within hyperedges are ordered in a similar core-periphery fashion, with the greatest developmental effects occurring in networked hyperedges within the functional core. Taken together, these results reveal a novel decomposition of the network organization of human brain, and further provide a new perspective on the role of local structures that emerge across neurodevelopment. Hum Brain Mapp 38:3823-3835, 2017. (c) 2017 Wiley Periodicals, Inc.
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Details
- Title
- Functional hypergraph uncovers novel covariant structures over neurodevelopment
- Creators
- Shi Gu - Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USAMuzhi Yang - Univ Penn, Appl Math & Computat Sci Grad Grp, Philadelphia, PA 19104 USAJohn D. Medaglia - Moss Rehabil Res Inst, Elkins Pk, PA USARuben C. Gur - Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USARaquel E. Gur - Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USATheodore D. Satterthwaite - Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USADanielle S. Bassett - Univ Penn, Dept Elect & Syst Engn, Philadelphia, PA 19104 USA
- Publication Details
- Human brain mapping, v 38(8), pp 3823-3835
- Publisher
- Wiley
- Number of pages
- 13
- Grant note
- W911NF-10-2-0022; W911NF-14-1-0679 / Army Research Office R01NS099348 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) 2-R01-DC-009209-11; 1R01HD086888-01; R01-MH107235; R01-MH107703; R01MH109520; R21-MH-106799 / National Institute of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA BCS-1441502; CAREER PHY-1554488; BCS-1631550 / National Science Foundation; National Science Foundation (NSF) Army Research Laboratory; United States Department of Defense; US Army Research Laboratory (ARL) R01HD086888 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) Office of Naval Research R01MH107703; R21MH106799; MH089983; MH089924 / National Institute of Mental Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) R01MH109520 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) Alfred P. Sloan Foundation Penn Institute of Translational Medicine and Therapeutics John D. and Catherine T. MacArthur Foundation R01DC009209 / NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Deafness & Other Communication Disorders (NIDCD)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000404963900005
- Scopus ID
- 2-s2.0-85018874608
- Other Identifier
- 991019296973704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neuroimaging
- Neurosciences
- Radiology, Nuclear Medicine & Medical Imaging