Journal article
Functional near-infrared spectroscopy brain imaging predicts symptom severity in youth exposed to traumatic stress
JOURNAL OF PSYCHIATRIC RESEARCH, v 144, pp 494-502
Dec 2021
PMID: 34768071
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Functional near-infrared spectroscopy (fNIRS) is a non-invasive neuroimaging technique with the potential to enable the assessment of posttraumatic stress disorder (PTSD) brain biomarkers in an affordable and portable manner. Consistent with biological models of PTSD, functional magnetic resonance imaging (fMRI) and fNIRS studies of adults with trauma exposure and PTSD symptoms suggest increased activation in the dorsolateral prefrontal cortex (dlPFC) and ventrolateral PFC (vlPFC) in response to negative emotion stimuli. We tested this theory with fNIRS assessment among youth exposed to traumatic stress and experiencing PTSD symptoms (PTSS). A portable fNIRS system collected hemodynamic responses from (N = 57) youth with PTSS when engaging in a classic emotion expression task that included fearful and neutral faces stimuli. The General Linear Model was applied to identify cortical activations associated with the facial stimuli. Subsequently, a prediction model was established via a Support Vector Regression to determine whether PTSS severity could be predicted based on fNIRS-derived cortical response measures and individual demographic information. Results were consistent with findings from adult fMRI and fNIRS studies of PTSS showing increased activation in the d1PFC and vlPFC in response to negative emotion stimuli. Subsequent prediction analysis revealed ten features (i.e., cortical responses from eight frontocortical fNIRS channels, age and sex) strongly correlated with PTSS severity (r = 0.65, p < .001). Our findings suggest the potential utility of fNIRS as a portable tool for the detection of putative PTSS brain biomarkers.
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Details
- Title
- Functional near-infrared spectroscopy brain imaging predicts symptom severity in youth exposed to traumatic stress
- Publication Details
- JOURNAL OF PSYCHIATRIC RESEARCH, v 144, pp 494-502
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD; OXFORD
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000720825600010
- Scopus ID
- 2-s2.0-85118658515
- Other Identifier
- 991021860750204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Psychiatry