Journal article
Functional organization of V2a-related locomotor circuits in the rodent spinal cord
Annals of the New York Academy of Sciences, v 1198(1), pp 85-93
01 Jan 2010
PMID: 20536923
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Studies of mammalian locomotion have been greatly facilitated by the use of the isolated rodent spinal cord preparation that retains the locomotor circuits needed to execute the movement. Physiological and molecular genetic experiments in this preparation have started to unravel the basic circuit organization responsible for walking in mammals. Here, we review these experiments with a focus on the functional role of excitatory V2a interneurons in the mammalian locomotor network. With regard to these neurons and other network structures we also discuss similarities and differences between the mammalian walking central pattern generator (CPG) and the fish swimming CPG.
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Details
- Title
- Functional organization of V2a-related locomotor circuits in the rodent spinal cord
- Creators
- Kimberly J. Dougherty - Karolinska InstitutetOle Kiehn - Karolinska Institutet
- Contributors
- L ZiiskindConhaim (Editor)Fetcho (Editor)S Hochman (Editor)A B MacDermott (Editor)PSG Stein (Editor)
- Publication Details
- Annals of the New York Academy of Sciences, v 1198(1), pp 85-93
- Series
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Number of pages
- 9
- Grant note
- Swedish Medical Research Council; Swedish Medical Research Council (SMRC) R01NS040795-08 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Hjarnfonden Wings for Life Friends of Karolinska Institutet EU; European Commission 0701166 / NSF; National Science Foundation (NSF) R01NS040795 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; College of Medicine; Drexel University
- Web of Science ID
- WOS:000281413900009
- Scopus ID
- 2-s2.0-77954613713
- Other Identifier
- 991020099208304721
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- Web of Science research areas
- Neurosciences