Journal article
Functional reconfiguration of cerebellum-cerebral neural loop in schizophrenia following electroconvulsive therapy
Psychiatry research. Neuroimaging, v 320, pp 111441-111441
01 Mar 2022
PMID: 35085957
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Recent evidence highlights the role of the cerebellum-cerebral loop in the pathophysiology of schizophrenia (SZ). Electroconvulsive therapy (ECT) is clinically applied to augment the effect of antipsychotic drugs. The study aims to address whether the cerebellum-cerebral loop is involved in the mechanisms of ECT's augmentation effect. Forty-two SZ patients and 23 healthy controls (HC) were recruited and scanned using resting-state functional MRI (rs-fMRI). Twenty-one patients received modified ECT plus antipsychotics (MSZ group), and 21 patients took antipsychotics only (DSZ group). All patients were re-scanned four weeks later. Brain functional network was constructed according to the graph theory. The sub-network exhibited longitudinal changes after ECT or medications were constructed. For the MSZ group, a sub-network involving default-mode network and cerebellum showed significant longitudinal changes. For the DSZ group, a different sub-network involving the thalamus, frontal and occipital cortex was found to be altered in the follow-up scan. In addition, the changing FC of the left cerebellar crus2 region was correlated with the changing scores of the psychotic symptoms only in the MSZ group but not in the DSZ group. In conclusion, the cerebral-cerebellum loop is possibly involved in the antipsychotic mechanisms of ECT for schizophrenia.
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Details
- Title
- Functional reconfiguration of cerebellum-cerebral neural loop in schizophrenia following electroconvulsive therapy
- Creators
- Hao Hu - Shanghai Mental Health CenterYuchao Jiang - University of Electronic Science and Technology of ChinaMengqing Xia - Shanghai Mental Health CenterYingying Tang - Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Sch Med, Shanghai 200030, Peoples R ChinaTianhong Zhang - Shanghai Mental Health CenterHuiru Cui - Shanghai Mental Health CenterJunjie Wang - Soochow Univ, Suzhou Psychiat Hosp, Inst Mental Hlth, Affiliated Guangji Hosp, Suzhou 215137, Jiangsu, Peoples R ChinaLihua Xu - Shanghai Mental Health CenterAdrian Curtin - Shanghai Jiao Tong UniversityJianhua Sheng - Shanghai Mental Health CenterXinyi Cao - Shanghai Mental Health CenterQian Guo - Shanghai Mental Health CenterYuping Jia - Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Sch Med, Shanghai 200030, Peoples R ChinaChunbo Li - Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Sch Med, Shanghai 200030, Peoples R ChinaZhen Wang - Shanghai Mental Health CenterCheng Luo - University of Electronic Science and Technology of ChinaJijun Wang - Suzhou Guangji Hospital
- Publication Details
- Psychiatry research. Neuroimaging, v 320, pp 111441-111441
- Publisher
- Elsevier
- Number of pages
- 10
- Grant note
- DLY201817; 20190102 / Clinical Research Center at Shanghai Jiaotong University School of Medicine 19MC1911100 / Shanghai Clinical Research Center for Mental Health 2018SHZDZX01; 2018SHZDZX05 / Shanghai Municipal Science and Technology Major Project BX2021078 / China Postdoctoral Science Foundation CRC2018ZD01; CRC2018ZD04; CRC2018YB01; CRC2019ZD02; 2020-FX-02 / Clinical Research Center at Shanghai Mental Health Center 2019-QH-01 / Qihang Foundation of Shanghai Mental Health Center 19411950800; 16ZR1430500; 19411969100; 19410710800; 21ZR1481500; 20ZR1448600; 21S31903100; 19ZR14451 / Shanghai Science and Technology Committee Foundations 19411969400 / Science and Technology Commission of Shanghai Municipality; Science & Technology Commission of Shanghai Municipality (STCSM) GWV-10.1-XK18 / Project of the Key Discipline Construction, Shanghai 3-Year Public Health Action Plan 82151314; 81971251; 81671329; 81871050; 82171497; 82101582; 82001406 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) 2018-FX-04 / Fund for Talents by Shanghai Mental Health Center GWV-10.2-YQ44 / Excellent Talents Training Project of Shanghai Municipal Commission of Health
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000748417400002
- Scopus ID
- 2-s2.0-85123342408
- Other Identifier
- 991019168445504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Neuroimaging
- Psychiatry