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Functionalization-induced self-assembly under ambient conditions via thiol-epoxide "click" chemistry
Journal article   Peer reviewed

Functionalization-induced self-assembly under ambient conditions via thiol-epoxide "click" chemistry

David H. Howe, Ken J. Jenewein, James L. Hart, Mitra L. Taheri and Andrew J. D. Magenau
Polymer chemistry, v 11(2), pp 298-303
14 Jan 2020

Abstract

Physical Sciences Polymer Science Science & Technology
Polymer micelles were formed using thiol-epoxide "click" chemistry to trigger functionalization-induced self-assembly (FISA) of block copolymers by modifying a reactive glycidyl methacrylate block with solvophobes. Ambient conditions, polymer concentrations up to 10 wt%, and an array of functional thiols were found effective for nanoparticle synthesis. Real-time analysis enabled direct observation of the self-assembly process, revealing mechanistic details and a critical degree of functionalization required for micellization.

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Domestic collaboration
Web of Science research areas
Polymer Science
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