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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Fundamental role of axial stress in compensatory adaptations by arteries
Journal of biomechanics, v 42(1), pp 1-8
05 Jan 2009
PMID: 19070860
Abstract
Arteries exhibit a remarkable ability to adapt to diverse genetic defects and sustained alterations in mechanical loading. For example, changes in blood flow induced wall shear stress tend to control arterial caliber and changes in blood pressure induced circumferential wall stress tend to control wall thickness. We Submit, however, that the axial component of wall stress plays a similarly fundamental role in controlling arterial geometry, Structure, and function, that is, compensatory adaptations. This observation comes from a review of findings reported in the literature and a comparison Of four recent Studies from Our laboratory that quantified changes in the biaxial mechanical Properties of mouse carotid arteries in cases of altered cell-matrix interactions, extracellular matrix composition, blood pressure, or axial extension. There is, therefore, a pressing need to include the fundamental role of axial wall Stress in conceptual and theoretical models of arterial growth and remodeling and, consequently, there is a need for increased attention to evolving biaxial mechanical properties in cases of altered genetics and mechanical stimuli. (C) 2008 Elsevier Ltd. All rights reserved.
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Details
- Title
- Fundamental role of axial stress in compensatory adaptations by arteries
- Creators
- J. D. Humphrey - Texas A&M UniversityJ. F. Eberth - Texas A&M UniversityW. W. Dye - Texas A&M UniversityR. L. Gleason - The Wallace H. Coulter Department of Biomedical Engineering
- Publication Details
- Journal of biomechanics, v 42(1), pp 1-8
- Publisher
- Elsevier
- Number of pages
- 8
- Grant note
- R01HL080415 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R01EB008366 / NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB) HL-64372; HL-80415; HL-86418; EB-08366 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000263191300001
- Scopus ID
- 2-s2.0-58149468382
- Other Identifier
- 991021902502104721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biophysics
- Engineering, Biomedical