Journal article
Future applications of fluorescence lifetime imaging ophthalmoscopy in neuro-ophthalmology, neurology, and neurodegenerative conditions
Frontiers in neurology, v 16, 1493876
2025
PMID: 40125394
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Fluorescence lifetime imaging ophthalmoscopy (FLIO) has emerged as an innovative advancement in retinal imaging, with the potential to provide in vivo non-invasive insights into the mitochondrial metabolism of the retina. Traditional retinal imaging, such as optical coherence tomography (OCT) and fundus autofluorescence (FAF) intensity imaging, focus solely on structural changes to the retina. In contrast, FLIO provides data that may reflect retinal fluorophore activity, some of which may indicate mitochondrial metabolism. This review builds upon the existing literature to describe the principles of FLIO and established uses in retinal diseases while introducing the potential for FLIO in neurodegenerative conditions.
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Details
- Title
- Future applications of fluorescence lifetime imaging ophthalmoscopy in neuro-ophthalmology, neurology, and neurodegenerative conditions
- Creators
- Daniel M. Markowitz - Drexel UniversityElizabeth Affel - Thomas Jefferson UniversityGyorgy Hajnoczky - Thomas Jefferson UniversityRobert C. Sergott (Corresponding Author) - Wills Eye Hospital
- Publication Details
- Frontiers in neurology, v 16, 1493876
- Publisher
- Frontiers Media Sa
- Number of pages
- 18
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:001449064000001
- Scopus ID
- 2-s2.0-105000721034
- Other Identifier
- 991022197404104721
UN Sustainable Development Goals (SDGs)
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Source: SDGs in the Output
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences