Logo image
Back
GEC-ESTRO (ACROP)-ABS-CBG Consensus Brachytherapy Target Definition Guidelines for Recurrent Endometrial and Cervical Tumors in the Vagina
Journal article   Open access   Peer reviewed

GEC-ESTRO (ACROP)-ABS-CBG Consensus Brachytherapy Target Definition Guidelines for Recurrent Endometrial and Cervical Tumors in the Vagina

Mitchell Kamrava, Eric Leung, Francois Bachand, Sushil Beriwal, Cyrus Chargari, David D'Souza, Beth Erickson, Lars Fokdal, Kathy Han, Matthew Harkenrider, …
International journal of radiation oncology, biology, physics, v 115(3), pp 654-663
01 Mar 2023
DOI: https://doi.org/10.1016/j.ijrobp.2022.09.072
PMID: 36191741
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://pure.amsterdamumc.nl/ws/files/163473184/Gec-estro-acropabscbg-consensus-brachytherapy-target-definition-guidelines-for-recurrent-endometrial-and-cervical-tu.pdfView
Open

Abstract

Brachytherapy - methods Canada Consensus Female Humans Magnetic Resonance Imaging - methods Neoplasm Recurrence, Local - diagnostic imaging Neoplasm Recurrence, Local - radiotherapy Radiotherapy Planning, Computer-Assisted Uterine Cervical Neoplasms - diagnostic imaging Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - radiotherapy Vagina - diagnostic imaging
Representatives from the Gynecologic Groupe European de Curietherapie-European Society for Radiation Therapy and Oncology (GYN GEC-ESTRO), the American Brachytherapy Society (ABS), and the Canadian Brachytherapy Group (CBG) met to develop international consensus recommendations for target definitions for image-guided adaptive brachytherapy for vaginal recurrences of endometrial or cervical cancer. Seventeen radiation oncologists and 2 medical physicists participated. Before an in-person meeting each participant anonymously contoured 3 recurrent endometrial/cervical cancer cases. Participants contoured the residual gross primary tumor volume (GTV-T ), a high-risk clinical target volume (CTV-T ), and an intermediate-risk clinical target volume (CTV-T ), on T2-weighted magnetic resonance images (MRIs). All contours were drawn using Falcon EduCase. Contours were reviewed at an in-person meeting during which a consensus document was created defining agreed-upon target definitions (Trial 1). After establishing these definitions, the group was sent one of the cases again (recurrent cervical cancer vaginal recurrence) and asked to contour the targets again (Trial 2). The Computerized Environment for Radiation Research (CERR) software (The Mathworks, Natwick, MA) was used to analyze the contours. Kappa statistics were generated to assess level of agreement between contours. A conformity index (CI), defined as the ratio between the intersection and union volume of a given pair of contours, was calculated. A simultaneous truth and performance level estimation (STAPLE) contour was created for the CTV-T and CTV-T for the postmeeting case. Consensus definitions for GTV-T , CTV-T , and CTV-T were established. Kappa statistics (Trial 1/Trial 2) for GTV-T , CTV-T , and CTV-T were 0.536/0.583, 0.575/0.743 and 0.522/0.707. Kappa statistics for Trial 2 for the CTV-T and CTV-T showed "substantial" agreement while the GTV-T remained at moderate agreement. This consensus provides recommendations to facilitate future collaborations for MRI-guided adaptive brachytherapy target definitions in endometrial/cervical vaginal recurrences.

Metrics

3 Record Views
27 citations in Web of Science
24 citations in Scopus

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Oncology
Radiology, Nuclear Medicine & Medical Imaging
Logo image