Journal article
GSK-3β activity and hyperdopamine-dependent behaviors
Neuroscience and biobehavioral reviews, v 35(3), pp 645-654
Jan 2011
PMID: 20727368
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Dopamine plays important roles in normal brain function and many neuropsychiatric disorders. Classically, dopamine receptors are positively coupled to G protein-mediated signaling to regulate cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA)-dopamine and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32) and Ca(2+) pathways. However, emerging evidence indicates that under hyperdopaminergic conditions, the protein kinase B (Akt)-glycogen synthase kinase 3β (GSK-3β) signaling cascade may mediate dopamine actions via D(2)-like receptors. This cAMP-independent signaling pathway involves the regulation of downstream synaptic targets, e.g., AMPA receptor, NMDA receptors, and thus synaptic plasticity. Here we provide an overview of how this novel signaling pathway relays dopamine receptor-mediated responses, particularly hyperdopamine-dependent behaviors. We discuss the relevance of the Akt/GSK-3β signaling cascade for the expression of dopamine-dependent behaviors and the drug actions associated with dopaminergic systems.
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Details
- Title
- GSK-3β activity and hyperdopamine-dependent behaviors
- Creators
- Yan-Chun Li - Department of Neurobiology & Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USAWen-Jun Gao
- Publication Details
- Neuroscience and biobehavioral reviews, v 35(3), pp 645-654
- Publisher
- Elsevier; United States
- Grant note
- R21MH232307 / NIMH NIH HHS R21 MH079117-01A1 / NIMH NIH HHS R01MH085666 / NIMH NIH HHS R01 MH085666 / NIMH NIH HHS R01 MH085666-03 / NIMH NIH HHS R21 MH079117 / NIMH NIH HHS R01 MH085666-02 / NIMH NIH HHS R01 MH085666-01A1 / NIMH NIH HHS R21 MH079117-02 / NIMH NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000286639900023
- Scopus ID
- 2-s2.0-78649908226
- Other Identifier
- 991014877977804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Behavioral Sciences
- Neurosciences