Journal article
Gag-p6 Tsg101 binding site duplications in maternal-infant HIV infection
AIDS research and human retroviruses, v 21(3), pp 191-199
Mar 2005
PMID: 15795524
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Prevalence and patterns of HIV p6 duplications in HIV-1 mother-to-baby transmission are examined. Resistance genotyping was performed in a multisite U.S. study of antiretroviral resistance in vertical transmission. Sequence data were used in secondary analyses of HIV genetic variation. Two hundred sixty HIV viral RNA samples from HIV-infected pregnant women and their infants were analyzed with a commercial resistance genotyping kit. Chromatograms were examined for variability in the 3' region of gag. From 103 mother-baby sets, 190 samples gave readable p6 sequence. Of 103 mother-baby sets, 20 (19%) showed duplication of between 3 and 12 codons ending at the PTAPP motif of p6. When maternal p6 duplication was present and the p6 sequence was available from both maternal and infant isolates, all (seven of seven) infants had p6 duplications, but two cases showed discordancies between maternal and infant sequences. The prevalence of p6 duplication varied among geographical sites, ranging from 4 of 43 families (9%, Puerto Rico and New York sites) to 16 of 60 families (27%, Massachusetts, Texas, and Illinois). The presence of p6 duplication was not associated with differences in transmission, viral load, or disease progression in the infants, but showed a trend toward association with lower maternal CD4 count. Substantial p6 variation data are generated by resistance genotyping. PTAP duplication is prevalent in this group of HIV-infected women and infants. The duplication is efficiently transmitted from mother to infant, is present at variable prevalence at different geographic sites, and shows no clear association with vertical transmission risks.
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Details
- Title
- Gag-p6 Tsg101 binding site duplications in maternal-infant HIV infection
- Creators
- Robert C Colgrove - Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA. robin@hms.harvard.eduAmy MilletGreta R BauerJane PittSeth L Welles
- Publication Details
- AIDS research and human retroviruses, v 21(3), pp 191-199
- Publisher
- Mary Ann Liebert; United States
- Grant note
- HD-3-6117 / NICHD NIH HHS U01 AI 34841 / NIAID NIH HHS U01 AI 34856 / NIAID NIH HHS U01 AI 34858 / NIAID NIH HHS RR00188 / NCRR NIH HHS R01 AI39144 / NIAID NIH HHS R0I-IID-25714 / PHS HHS N01 AI 85339 / NIAID NIH HHS RR00645 / NCRR NIH HHS U01 AI 34840 / NIAID NIH HHS U01 AI 34842 / NIAID NIH HHS 1 U01 AI 50274-01 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000228187000001
- Scopus ID
- 2-s2.0-16444376105
- Other Identifier
- 991014878395104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases
- Virology