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Galectin-3 and incident cognitive impairment in REGARDS, a cohort of blacks and whites
Journal article   Open access   Peer reviewed

Galectin-3 and incident cognitive impairment in REGARDS, a cohort of blacks and whites

Anand Venkatraman, Peter Callas, Leslie A. McClure, Fred Unverzagt, Garima Arora, Virginia Howard, Virginia G. Wadley, Mary Cushman and Pankaj Arora
Alzheimer's & dementia : translational research & clinical interventions, v 4(1), pp 165-172
2018
DOI: https://doi.org/10.1016/j.trci.2018.03.006
PMID: 29756004
url
https://doi.org/10.1016/j.trci.2018.03.006View
Published, Version of Record (VoR)CC BY-NC-ND V4.0,  Open

Abstract

Biomarkers Cognitive impairment Epidemiology Galectin-3 Incidence Risk factors
The relationship between serum galectin-3 and incident cognitive impairment was analyzed in the Reasons for Geographic and Racial Differences in Stroke study. Baseline galectin-3 was measured in 455 cases of incident cognitive impairment and 546 controls. Galectin-3 was divided into quartiles based on the weighted distribution in the control group, and the first quartile was the referent. There was an increasing odds of cognitive impairment across quartiles of galectin-3 (odds ratios, 1.00 [0.68–1.46], 1.45 [1.01–2.10], and 1.58 [1.10–2.27] relative to the quartile 1; P trend = .003) in an unadjusted model, which persisted after adjusting for age, sex, and race (P = .004). Adjustment for cardiovascular risk factors greatly attenuated this association (odds ratios, 0.97 [0.60–1.57], 1.52 [0.94–2.46], and 1.27 [0.76–2.12]; P = .15). The association differed by diabetes status (P interaction, .007). Among nondiabetics (293 cases, 411 controls), those with galectin-3 in the fourth compared with first quartile had an odds ratio of 1.6 (0.95–2.99; P trend, .02). In diabetics, the odds ratio was 0.23 (0.04–1.33). Serum galectin-3 was associated with increased risk of incident cognitive impairment in a large cohort study of blacks and whites but only in nondiabetics.

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