Journal article
Gallbladder Disease and Risk of Type 2 Diabetes in Postmenopausal Women: A Women's Health Initiative Study
American journal of epidemiology, v 191(8), pp 1374-1382
23 Jul 2022
PMID: 35434732
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Studies have suggested that adults with gallbladder disease have increased risk of type 2 diabetes. This prospective cohort study assessed the risk of type 2 diabetes in postmenopausal women with gallbladder disease. Data from women enrolled in the Women's Health Initiative from 1993 to 2005, aged 50-79 years (mean = 63.2; standard deviation, 7.2), were analyzed. Cox proportional hazards regression models were used to estimate the risk of type 2 diabetes associated with gallbladder disease. There were 8,896 new cases of type 2 diabetes after 1,025,486 person-years of follow-up. Gallbladder disease was significantly associated with type 2 diabetes (hazard ratio = 1.52; 95% confidence interval (CI): 1.38,1.67). The observed risk of type 2 diabetes in women with both gallbladder disease and central obesity was 37% higher than expected (relative excess risk due to interaction = 0.37, 95% CI: 0.11,0.63) on the additive scale. The hazard ratios for type 2 diabetes associated with gallbladder disease were 1.25 (95% CI: 1.19,1.32) and 1.48 (95% CI: 1.34,1.63) in women with and without central obesity, respectively, on the multiplicative scale. Results of this study support further studies to determine whether interventions in older women with gallbladder disease would reduce type 2 diabetes risk, especially among those with central obesity. Future research should examine the pathophysiological basis of the association between gallbladder disease and type 2 diabetes.
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Details
- Title
- Gallbladder Disease and Risk of Type 2 Diabetes in Postmenopausal Women: A Women's Health Initiative Study
- Creators
- Ako Adams Ako (Corresponding Author) - Penn State Milton S. Hershey Medical CenterYvonne L. Michael - Drexel University, Urban Health CollaborativeLucy F. Robinson - Drexel University, Epidemiology and BiostatisticsJean Wactawski-Wende - University at Buffalo, State University of New YorkAladdin H. Shadyab - Human Longevity (United States)Lorena Garcia - University of California, DavisBede N. Nriagu - Drexel Univ, Dornsife Sch Publ Hlth, Dept Epidemiol & Biostat, Philadelphia, PA 19104 USANazmus Saquib - College Station Medical CenterRami Nassir - Umm Al Quraa Univ, Coll Med, Dept Pathol, Mecca, Saudi ArabiaSimin Liu - Brown UniversityRobert B. Wallace - University of Iowa
- Publication Details
- American journal of epidemiology, v 191(8), pp 1374-1382
- Publisher
- Oxford University Press
- Number of pages
- 9
- Grant note
- 75N92021D00001; 75N92021D00002; 75N92021D00003; 75N92021D00004; 75N92021D00005 / National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Epidemiology and Biostatistics
- Web of Science ID
- WOS:000808486300001
- Scopus ID
- 2-s2.0-85135596886
- Other Identifier
- 991019167713304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health