Journal article
Gamma Knife radiosurgery for brain metastases from small-cell lung cancer: Institutional experience over more than a decade and review of the literature
Journal of radiosurgery and SBRT, v 6(1), pp 35-43
01 Jan 2019
PMID: 30775073
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Introduction: In the present study, we reviewed the efficacy of stereotactic radiosurgery (SRS) alone or in combination with WBRT, for the treatment of patients with BM secondary to SCLC. We further identified patient and treatment specific factors that correlated with improved survival.
Methods: Forty-one patients treated with GKRS for BM secondary to SCLC from 2004 to 2017 at the University of Virginia were identified with histopathologically proven SCLC and included in the study.
Results: Following the first GKRS treatment, the median survival was 6 months (1-41 months). There was no statistical difference in overall survival and tumor control between the patients who had PCI, WBRT or upfront GKRS. The only factor associated with decreased OS after the diagnosis of BM from SCLC was active extracranial disease (P=0.045, HR=2.354).
Conclusion: Stereotactic radiosurgery is a reasonable treatment option for patients with brain metastases of SCLC who had PCI or WBRT failure.
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Details
- Title
- Gamma Knife radiosurgery for brain metastases from small-cell lung cancer: Institutional experience over more than a decade and review of the literature
- Creators
- Diogo Cordeiro - University of VirginiaZhiyuan Xu - University of VirginiaMatthew Shepard - University of VirginiaDarrah Sheehan - University of VirginiaChelsea Li - University of VirginiaJason Sheehan - University of Virginia
- Publication Details
- Journal of radiosurgery and SBRT, v 6(1), pp 35-43
- Publisher
- Old City Publishing Inc
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:000455959500005
- Scopus ID
- 2-s2.0-85062457875
- Other Identifier
- 991022155294404721
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- Web of Science research areas
- Surgery