Journal article
Gastric and Pancreatic Function in Patients with End-Stage Renal Disease
Journal of clinical gastroenterology, v 4(4), pp 321-324
Aug 1982
PMID: 7119408
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Gastroduodenal disease such as peptic ulcer and duodenitis is increased in patients with end-stage renal disease. Gastric hypersecretion of acid proposed as the underlying mechanism has been disputed because peptic ulcer has occurred even in those with normal or low gastric acid secretion. We studied the pancreatic exocrine secretion of bicarbonate (HCO3) and the concentration of plasma pepsinogens in addition to gastric acid secretion in 15 patients on chronic hemodialysis, 10 patients with previous renal transplantation and compared them with 10 subjects without gastrointestinal or renal disease. We confirmed hypersecretion of gastric acid in renal patients on chronic hemodialysis but not in transplant patients. In addition, we found basal hyposecretion of HCO3 and hyperpepsinogenemia in both renal groups. These observations suggest that the high incidence of gastroduodenal disease in end-stage renal disease might, in part, be due to the simultaneous occurrence of gastric acid hypersecretion, basal hyposecretion of HCO3 by the pancreas, and hyperpepsinogenemia.
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Details
- Title
- Gastric and Pancreatic Function in Patients with End-Stage Renal Disease
- Creators
- Vicente Dinoso - Divisions of Gastroenterology and Nephrology, Hah-nemann Medical College and Hospital (VPD, SNSM, ALS, HRC, SS, PL), and the Division of Nephrology, Metropolitan Hospital (WAN), Philadelphia, PennsylvaniaS MurthyAnne SarisHarris ClearfieldPatricia LyonsWilliam NickeySimon Simonian
- Publication Details
- Journal of clinical gastroenterology, v 4(4), pp 321-324
- Publisher
- Lippincott-Raven Publishers
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Nephrology (and Hypertension); [Retired Faculty]
- Web of Science ID
- WOS:A1982PB58000005
- Scopus ID
- 2-s2.0-0020048131
- Other Identifier
- 991019183947404721
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- Web of Science research areas
- Gastroenterology & Hepatology