Journal article
Gastrointestinal Signs and Symptoms Related to Inflammatory Bowel Disease in Patients With Moderate-to-Severe Psoriasis
Journal of drugs in dermatology, v 17(12), pp 1298-1308
01 Dec 2018
PMID: 30586262
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Psoriasis (PsO) is a chronic inflammatory skin disorder that may be associated with comorbidities, including inflammatory bowel disease (IBD), given common immunopathogenic mechanisms. Whether PsO patients are more likely to suffer from gastrointestinal (GI) signs and symptoms has not been well-characterized. Understanding their prevalence in PsO patients may inform strategies to evaluate for GI signs and symptoms, screen for those at risk for IBD, and guide choice of therapy.
Objective: To assess the prevalence of GI signs and symptoms in patients with moderate-to-severe PsO.
Methods: An Internet-based survey was conducted to evaluate GI signs and symptoms in patients with self-reported moderate-to severe PsO and non-PsO controls. The impact of PsO severity and presence of psoriatic arthritis (PsA) [self-reported and/or screened positive on the Psoriatic Arthritis Screening and Evaluation (PASE) questionnaire] on prevalence of GI signs and symptoms was also assessed. The survey included questions about PsO, comorbidities, demographics, and GI signs and symptoms. Questions related to GI signs and symptoms were used to calculate a modified CalproQuest* score to identify patients at increased risk for IBD.
Results: Survey responses were collected from 740 PsO patients and 1411 non-PsO controls. With the exception of age, demographics were generally comparable between groups. All six GI signs and symptoms assessed (belly pain, feeling full/bloated, diarrhea, mucus in stool, blood in stool, and unintentional weight loss) were more prevalent in PsO patients compared with non-PsO controls, and a higher proportion of PsO patients also had a positive CalproQuest* result. In addition, both more severe PsO and concomitant PsA were associated with a higher prevalence of GI signs and symptoms and a positive CalproQuest*.
Conclusions: This study suggests that PsO patients, including those with PsA, have a higher prevalence of GI signs and symptoms. Physicians should recognize and consider this concern in PsO patient management.
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Details
- Title
- Gastrointestinal Signs and Symptoms Related to Inflammatory Bowel Disease in Patients With Moderate-to-Severe Psoriasis
- Creators
- Steven R. Feldman - Wake Forest Sch Med, Dept Dermatol, Winston Salem, NC 27101 USABhaskar Srivastava - Janssen Sci Affairs LLC, Horsham, PA USAJill Abell - Janssen Sci Affairs LLC, Horsham, PA USATimothy Hoops - Janssen Sci Affairs LLC, Horsham, PA USASteve Fakharzadeh - Janssen Global Serv LLC, Titusville, NJ USASoumya D. Chakravarty - Product Innovation and Engineering (United States, Saint James) - LLCErik Muser - Janssen Sci Affairs LLC, Horsham, PA USADanielle Dungee - Janssen Sci Affairs LLC, Horsham, PA USASean T. Quinn - Janssen Sci Affairs LLC, Horsham, PA USAMegan Leone-Perkins - HealthiVibe, Arlington, VA USAMichael D. Kappelman - Univ N Carolina, Div Pediat Gastroenterol, Chapel Hill, NC 27515 USA
- Publication Details
- Journal of drugs in dermatology, v 17(12), pp 1298-1308
- Publisher
- Journal Of Drugs In Dermatology
- Number of pages
- 11
- Grant note
- Janssen Scientific Affairs, LLC
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Rheumatology
- Web of Science ID
- WOS:000453941400005
- Scopus ID
- 2-s2.0-85059242050
- Other Identifier
- 991019167581704721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Dermatology