Journal article
Gender differences in genetic susceptibility for lung cancer
Lung cancer (Amsterdam, Netherlands), v 30(3), pp 153-160
2000
PMID: 11137199
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In contrast to men, the incidence of lung cancer among women has increased over the past decade. The basis for this increase among female smokers remains unknown. Surgical patients with a diagnosis of lung cancer and control subjects without a history of malignancy completed a smoking questionnaire and donated a blood sample. DNA was extracted from peripheral mononuclear cells and genotyped for polymorphisms in cytochrome P450 1A1 (
CYP1A1) (exon 7) and glutathione
S-transferase M1 (
GSTM1) (null). No gender differences in either age at diagnosis or histological subtype were observed among lung cancer patients. In both patients (
n=180) and controls (
n=163), females smoked significantly less than males. The pack-year history associated with adenocarcinoma was smaller than that for squamous cell carcinoma. No significant association was observed between the
GSTM1 null genotype and cancer risk. However, women had a larger cancer risk than men (odds ratio 4.98 vs. 1.37) if they possessed the mutant
CYP1A1 genotype. Female cancer patients were significantly more likely than female controls to have both the
CYP1A1 mutation and
GSTM1 null genotype. The combined variant genotypes conferred an odds ratio of 6.54 for lung cancer in women versus 2.36 for men, independent of age or smoking history. These data suggest that polymorphisms in
CYP1A1 and
GSTM1 contribute to the increased risk of females for lung cancer.
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Details
- Title
- Gender differences in genetic susceptibility for lung cancer
- Creators
- Carolyn M Dresler - Department of Surgical Oncology, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USACori Fratelli - Division of Population Science, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USAJames Babb - Division of Population Science, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USALynette Everley - Division of Population Science, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USAAlison A Evans - Division of Population Science, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USAMargie L Clapper - Division of Population Science, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
- Publication Details
- Lung cancer (Amsterdam, Netherlands), v 30(3), pp 153-160
- Publisher
- Elsevier Ireland Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000165765600001
- Scopus ID
- 2-s2.0-0034530103
- Other Identifier
- 991014877662304721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Oncology
- Respiratory System