Journal article
Gene Expression Networks Across Multiple Tissues Are Associated with Rates of Molecular Evolution in Wild House Mice
Genes, v 10(3), p225
18 Mar 2019
PMID: 30889893
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Interactions between genes can influence how selection acts on sequence variation. In gene regulatory networks, genes that affect the expression of many other genes may be under stronger evolutionary constraint than genes whose expression affects fewer partners. While this has been studied for individual tissue types, we know less about the effects of regulatory networks on gene evolution across different tissue types. We use RNA-sequencing and genomic data collected from
to construct and compare gene co-expression networks for 10 tissue types. We identify tissue-specific expression and local regulatory variation, and we associate these components of gene expression variation with sequence polymorphism and divergence. We found that genes with higher connectivity across tissues and genes associated with a greater number of cross-tissue modules showed significantly lower genetic diversity and lower rates of protein evolution. Consistent with this pattern, "hub" genes across multiple tissues also showed evidence of greater evolutionary constraint. Using allele-specific expression, we found that genes with cis-regulatory variation had lower average connectivity and higher levels of tissue specificity. Taken together, these results are consistent with strong purifying selection acting on genes with high connectivity within and across tissues.
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Details
- Title
- Gene Expression Networks Across Multiple Tissues Are Associated with Rates of Molecular Evolution in Wild House Mice
- Creators
- Katya L Mack - Museum of Vertebrate ZoologyMegan Phifer-Rixey - Monmouth UniversityBettina Harr - Max Planck Institute for Evolutionary BiologyMichael W Nachman - Museum of Vertebrate Zoology
- Publication Details
- Genes, v 10(3), p225
- Publisher
- MDPI
- Grant note
- R01 GM074245 / NIH HHS R01 GM127468 / NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000464471600006
- Scopus ID
- 2-s2.0-85064702585
- Other Identifier
- 991021229908404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Genetics & Heredity