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Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Gene-by-Psychosocial Factor Interactions Influence Diastolic Blood Pressure in European and African Ancestry Populations: Meta-Analysis of Four Cohort Studies
International journal of environmental research and public health, v 14(12), p1596
18 Dec 2017
PMID: 29258278
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Inter-individual variability in blood pressure (BP) is influenced by both genetic and non-genetic factors including socioeconomic and psychosocial stressors. A deeper understanding of the gene-by-socioeconomic/psychosocial factor interactions on BP may help to identify individuals that are genetically susceptible to high BP in specific social contexts. In this study, we used a genomic region-based method for longitudinal analysis, Longitudinal Gene-Environment-Wide Interaction Studies (LGEWIS), to evaluate the effects of interactions between known socioeconomic/psychosocial and genetic risk factors on systolic and diastolic BP in four large epidemiologic cohorts of European and/or African ancestry. After correction for multiple testing, two interactions were significantly associated with diastolic BP. In European ancestry participants, outward/trait anger score had a significant interaction with the
genomic region (
= 0.0019). In African ancestry participants, depressive symptom score had a significant interaction with the
genomic region (
= 0.0048). This study provides a foundation for using genomic region-based longitudinal analysis to identify subgroups of the population that may be at greater risk of elevated BP due to the combined influence of genetic and socioeconomic/psychosocial risk factors.
Metrics
Details
- Title
- Gene-by-Psychosocial Factor Interactions Influence Diastolic Blood Pressure in European and African Ancestry Populations: Meta-Analysis of Four Cohort Studies
- Creators
- Jennifer A Smith - University of Michigan–Ann ArborWei Zhao - University of Michigan–Ann ArborKalyn Yasutake - University of Michigan–Ann ArborCarmella August - University of Michigan–Ann ArborScott M Ratliff - University of Michigan–Ann ArborJessica D Faul - University of Michigan–Ann ArborEric Boerwinkle - The University of Texas Health Science Center at HoustonAravinda Chakravarti - Johns Hopkins UniversityAna V Diez Roux - Department of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, PA 19104, USA. avd37@drexel.eduYan Gao - University of MississippiMichael E Griswold - University of MississippiGerardo Heiss - University of North CarolinaSharon L R Kardia - University of Michigan–Ann ArborAlanna C Morrison - The University of Texas Health Science Center at HoustonSolomon K Musani - University of MississippiStanford Mwasongwe - Jackson State UniversityKari E North - University of North CarolinaKathryn M Rose - University of North CarolinaMario Sims - University of MississippiYan V Sun - Emory UniversityDavid R Weir - University of Michigan–Ann ArborBelinda L Needham - University of Michigan–Ann Arbor
- Publication Details
- International journal of environmental research and public health, v 14(12), p1596
- Publisher
- MDPI
- Grant note
- HHSN268201300048C / NHLBI NIH HHS N01HC95169 / NHLBI NIH HHS HHSN268201100007C / NHLBI NIH HHS U01 HG004402 / NHGRI NIH HHS UL1 TR001881 / NCATS NIH HHS HHSN268201100005G / NHLBI NIH HHS R03 AG046389 / NIA NIH HHS N01HC95163 / NHLBI NIH HHS N01HC95166 / NHLBI NIH HHS HHSN268201100011C / NHLBI NIH HHS HHSN268201100011I / NHLBI NIH HHS HHSN268201100007I / NHLBI NIH HHS U01 AG009740 / NIA NIH HHS HHSN268201100010C / NHLBI NIH HHS UL1 RR025005 / NCRR NIH HHS HHSN268201100005C / NHLBI NIH HHS R01 HL059367 / NHLBI NIH HHS HHSN268201500003C / NHLBI NIH HHS HHSN268201300049C / NHLBI NIH HHS HHSN268201100005I / NHLBI NIH HHS N01HC95168 / NHLBI NIH HHS UL1 TR000040 / NCATS NIH HHS R01 HL101161 / NHLBI NIH HHS N01HC95165 / NHLBI NIH HHS P30 DK063491 / NIDDK NIH HHS N01HC95162 / NHLBI NIH HHS RC2 AG036495 / NIA NIH HHS R25 AG053227 / NIA NIH HHS N01HC95161 / NHLBI NIH HHS HHSN268201100012C / NHLBI NIH HHS N01HC95164 / NHLBI NIH HHS HHSN263201500003I / NIH HHS N01HC95167 / NHLBI NIH HHS HHSN268201100008I / NHLBI NIH HHS N02HL64278 / NHLBI NIH HHS N01HC95159 / NHLBI NIH HHS HHSN268201300047C / NHLBI NIH HHS HHSN268201100006C / NHLBI NIH HHS R01 MD011716 / NIMHD NIH HHS UL1 TR001079 / NCATS NIH HHS HHSN268201300046C / NHLBI NIH HHS RC4 AG039029 / NIA NIH HHS HHSN268201100008C / NHLBI NIH HHS N01HC95160 / NHLBI NIH HHS R01 HL086694 / NHLBI NIH HHS HHSN268201300050C / NHLBI NIH HHS R01 HL087641 / NHLBI NIH HHS HHSN268201100009C / NHLBI NIH HHS P60 MD002249 / NIMHD NIH HHS HHSN268201100009I / NHLBI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000423699400158
- Scopus ID
- 2-s2.0-85038869846
- Other Identifier
- 991019168702704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health