Journal article
Generalization of independent response model for toxic mixtures
Chemosphere (Oxford), v 34(4), pp 699-710
1997
PMID: 9569938
Abstract
Interaction between toxic compounds has long been known to researchers. Attempts to model this interaction have been based on two basic paradigms -- termed additivity and independence (1, 2). Previous models based on these assumptions focused on measuring the interaction between the compounds and then classifying the type of interaction as synergism, antagonism, additivity or independence (3, 4). The aim of this work is to present a generalization of the independent action hypothesis that is quantitatively capable of describing deviations regardless of the underlying single component dose response models. The mathematical framework of copulas is employed. This approach is then tested against data sets with both human health and ecological risk applications.
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Details
- Title
- Generalization of independent response model for toxic mixtures
- Creators
- Charles N Haas - Environmental Science and Engineering Institute Drexel University Philadelphia, PA 19104, USASean Patrick Kersten - Environmental Science and Engineering Institute Drexel University Philadelphia, PA 19104, USAKen Wright - Environmental Science and Engineering Institute Drexel University Philadelphia, PA 19104, USAMaurice J Frank - Department of Mathematics Illinois Institute of Technology Chicago, IL 60616, USAKaushik Cidambi - Environmental Science and Engineering Institute Drexel University Philadelphia, PA 19104, USA
- Publication Details
- Chemosphere (Oxford), v 34(4), pp 699-710
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Civil, Architectural, and Environmental Engineering
- Web of Science ID
- WOS:A1997WM67900003
- Scopus ID
- 2-s2.0-0031080577
- Other Identifier
- 991014878402304721
InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Environmental Sciences