Journal article
Generalized epilepsies: immunologic and inflammatory mechanisms
Seminars in pediatric neurology, v 21(3), pp 214-220
Sep 2014
PMID: 25510943
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This article focuses on the inflammatory processes in patients with generalized epilepsies. We specifically review the data regarding West, Lennox-Gastaut, and Landau-Kleffner syndromes as they have generalized clinical or electroencephalogram features. There is substantial evidence for a pathogenic implication of immune mechanisms in these epilepsies. Animal models and abnormalities in both cellular and humoral immunity support this hypothesis. They also appear to be particularly responsive to immunomodulatory therapies, which has raised the speculation that an unbalanced immune system may play an important role in the pathophysiology of these epileptic syndromes. In this article, we discuss clinical and experimental data that support the potential implication of immune mediated inflammation and immune response in the mechanism of these entities.
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Details
- Title
- Generalized epilepsies: immunologic and inflammatory mechanisms
- Creators
- Karen S Carvalho - Drexel UniversityDiana J Walleigh - St. Christopher's Hospital for ChildrenAgustín Legido - St. Christopher's Hospital for Children
- Publication Details
- Seminars in pediatric neurology, v 21(3), pp 214-220
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000346888000004
- Scopus ID
- 2-s2.0-84916942108
- Other Identifier
- 991019169639404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Pediatrics