Journal article
Generation and maintenance of human memory cells during viral infection
Springer seminars in immunopathology, v 28(3), pp 197-208
01 Nov 2006
PMID: 16967292
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Long-term maintenance of memory T cell response is the hallmark of immune protection and hence the holy grail of most vaccine development studies. Persistent memory cells, developed after either viral infection or vaccination, ensure the generation of an antiviral response upon reexposure to the pathogen. During acute viral infections, as in the case of measles and influenza viruses, strong T cell effector functions, which eradicate the virus and protect patients against reexposure, are achieved by the generation of persistent protective memory cells. However, in chronic infections, T cells drastically lose effector functions before acquiring a memory phenotype. Chronic infections can be categorized into infections where viremia is controlled and protective memory cells are maintained as in the case of EBV and CMV infections, or where the virus persists and memory cells are exhausted and disrupted as in the case of human immunodeficiency virus infection. In this review, we will discuss the different phenotypical and functional characteristics of memory cells subsets, the importance of the role they play during acute and chronic infections, and the mechanisms behind their effectiveness and persistence.
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Details
- Title
- Generation and maintenance of human memory cells during viral infection
- Creators
- Rabih Halwani - Centre Hospitalier de l’Université de MontréalMehrnoosh Doroudchi - Centre Hospitalier de l’Université de MontréalBader Yassine-Diab - Centre Hospitalier de l’Université de MontréalLoury Janbazian - Centre Hospitalier de l’Université de MontréalYu Shi - Centre Hospitalier de l’Université de MontréalElias A. Said - Centre Hospitalier de l’Université de MontréalElias K. HaddadRafick-Pierre Sekaly - Centre Hospitalier de l’Université de Montréal
- Publication Details
- Springer seminars in immunopathology, v 28(3), pp 197-208
- Publisher
- Springer Nature
- Number of pages
- 12
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Infectious Diseases (and HIV Medicine); Drexel University
- Web of Science ID
- WOS:000242136800002
- Scopus ID
- 2-s2.0-33751118475
- Other Identifier
- 991020100090704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology
- Pathology