Journal article
Genetic Diversity and Tissue Compartmentalization of the Hepatitis C Virus Genome in Blood Mononuclear Cells, Liver, and Serum from Chronic Hepatitis C Patients
Journal of virology, v 72(2), pp 1640-1646
Feb 1998
PMID: 9445070
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The degree of genetic variability in the hypervariable region 1 of hepatitis C virus (HCV) was analyzed by cloning and sequencing HCV genomes obtained in paired samples of serum, liver tissue, and peripheral blood mononuclear cells (PBMC) from four chronic hepatitis C patients. Genetic variability in serum was higher than in liver tissue or PBMC at the level of complexity (the number of different sequences obtained from each type of tissue) as well as at the level of genetic distance between all pairs of sequences within each tissue (compared by the Student
t
test;
P
< 0.001 for two patients and
P
< 0.01 for another). The spectrum of viral genomes differed among the three types of tissue, as shown by segregation of sequences according to their tissue of origin in phylogenetic analysis and by statistical analysis of mean genetic distances observed between sequences obtained from different tissues (
P
< 0.001), but sequences from liver tissue and PBMC were more closely related to each other than to those from serum.
Metrics
Details
- Title
- Genetic Diversity and Tissue Compartmentalization of the Hepatitis C Virus Genome in Blood Mononuclear Cells, Liver, and Serum from Chronic Hepatitis C Patients
- Creators
- Sonia Navas - Department of Hepatology, Fundación Jiménez Díaz, and Fundación Estudio Hepatitis Virales, Madrid, SpainJulio Martín - Department of Hepatology, Fundación Jiménez Díaz, and Fundación Estudio Hepatitis Virales, Madrid, SpainJuan Antonio Quiroga - Department of Hepatology, Fundación Jiménez Díaz, and Fundación Estudio Hepatitis Virales, Madrid, SpainInmaculada Castillo - Department of Hepatology, Fundación Jiménez Díaz, and Fundación Estudio Hepatitis Virales, Madrid, SpainVicente Carreño - Department of Hepatology, Fundación Jiménez Díaz, and Fundación Estudio Hepatitis Virales, Madrid, Spain
- Publication Details
- Journal of virology, v 72(2), pp 1640-1646
- Series
- Note
- Publisher
- American Society for Microbiology
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000071440200091
- Scopus ID
- 2-s2.0-0031932434
- Other Identifier
- 991014878266804721
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- Virology