Journal article
Genetic Polymorphisms in Metabolizing Enzymes and Susceptibility of Chromosomal Damage Induced by Vinyl Chloride Monomer in a Chinese Worker Population
Journal of occupational and environmental medicine, v 52(2), pp 163-168
01 Feb 2010
PMID: 20134343
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: To evaluate whether polymorphisms in metabolizing enzymes contributed to susceptibility of chromosomal damage induced by vinyl chloride monomer (VCM). Methods: Cytokinesis block micronucleus test was performed on 185 VCM-exposed workers and 41 control subjects to detect chromosomal damage in peripheral lymphocytes. The polymerase chain reaction and restriction fragment length polymorphism technique was applied to detect polymorphisms of GSTT1, GSTM1, GSTP1G/A, CYP2E1G/C. and CYP2D6G/C. Poisson regression analysis was performed. Results: Sex, age, VCM exposure, GSTP1, and CYP2E1 genotype can influence chromosomal damage. There was a 1.51-fold increased micronucleus frequency for GSTP1GG genotypes individuals compared with those GSTP1AA/GA genotype individuals (P < 0.05), the effect of polymorphism in CYP2E1 gene was more pronounced for allele C compared with allele G (P < 0.05). Conclusions: Polymorphisms of GSTP1G/A and CYP2E1G/C, which are potential susceptibility biomarkers of chromosomal damage in VCM-exposed worker.
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Details
- Title
- Genetic Polymorphisms in Metabolizing Enzymes and Susceptibility of Chromosomal Damage Induced by Vinyl Chloride Monomer in a Chinese Worker Population
- Creators
- Wei Wang - Fudan UniversityYu-lan Qiu - Fudan UniversityFang Ji - Fudan UniversityJing Liu - Fudan UniversityFen Wu - Fudan UniversityWen-bin Miao - Fudan UniversityYongliang Li - University of Illinois Urbana-ChampaignPaul W. Brandt-Rauf - University of Illinois Urbana-ChampaignZhao-lin Xia - Fudan University
- Publication Details
- Journal of occupational and environmental medicine, v 52(2), pp 163-168
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 6
- Grant note
- NSFC-30671740 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) R01-OH04192; P30-ES09089 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01OH004192 / NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA; National Institute for Occupational Safety & Health (NIOSH) P30ES009089 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) 08GWD12; 08GW2X0402 / Shanghai Bureau of Public Health
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Drexel University
- Web of Science ID
- WOS:000274491600008
- Scopus ID
- 2-s2.0-77049121307
- Other Identifier
- 991019323774204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health