Journal article
Genetic Predictors of Depressive Symptoms in the Look AHEAD Trial
Psychosomatic medicine, v 77(9), pp 982-992
01 Nov 2015
PMID: 26489030
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objectives Numerous studies have found elevated depressive symptoms among individuals with Type 2 diabetes, yet the mechanisms remain unclear. We examined whether genetic loci previously associated with depressive symptoms predict depressive symptoms among overweight/obese individuals with Type 2 diabetes or change in depressive symptoms during behavioral weight loss.
Methods The Illumina CARe iSelect (IBC) chip and Cardiometabochip were characterized in 2118 overweight or obese participants with Type 2 diabetes from Look AHEAD (Action for Health in Diabetes), a randomized trial to determine the effects of intensive life-style intervention and diabetes support and education on cardiovascular morbidity and mortality. Primary analyses focused on baseline Beck Depression Inventory (BDI) scores and depressive symptom change at 1 year.
Results Of eight single nucleotide polymorphisms (SNPs) in six loci, three a priori SNPs in two loci (chromosome 5: rs60271; LBR: rs2230419, rs1011319) were associated with baseline BDI scores, but in the opposite direction of prior research. In joint analysis of 90,003 IBC and Cardiometabochip SNPs, rs1543654 in the region of KCNE1 predicted change in BDI scores at Year 1 in diabetes support and education ( = -1.05, standard error [SE] = 0.21, p = 6.9 x 10(-7)) at the level of chip-wide significance, while also showing a nominal association with baseline BDI ( = 0.35, SE = 0.16, p = .026). Adjustment for antidepressant medication and/or limiting analyses to non-Hispanic white individuals did not meaningfully alter results.
Conclusions Previously reported genetic associations with depressive symptoms did not replicate in this cohort of overweight/obese individuals with Type 2 diabetes. We identified KCNE1 as a potential novel locus associated with depressive symptoms.
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Details
- Title
- Genetic Predictors of Depressive Symptoms in the Look AHEAD Trial
- Creators
- Jeanne M. McCaffery - Brown UniversityGeorge D. Papandonatos - Brown UniversityLucy F. Faulconbridge - University of PennsylvaniaBahar Erar - Icahn School of Medicine at Mount SinaiInga Peter - Wake Forest UniversityLynne E. Wagenknecht - Wake Forest UniversityNicholas M. Pajewski - Biostat (United States)Andrea Anderson - College Station Medical CenterThomas A. Wadden - College Station Medical CenterRena R. Wing - Brown UniversityLook AHEAD Res GrpEllen Stephanie Krauthamer Ewing - Drexel University
- Publication Details
- Psychosomatic medicine, v 77(9), pp 982-992
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 11
- Grant note
- Centers for Disease Control and Prevention; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA DK 046204 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA National Center on Minority Health and Health Disparities; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Minority Health & Health Disparities (NIMHD) Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) UL1TR001120; UL1TR001082 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) M01RR01066 / Massachusetts General Hospital Mallinckrodt General Clinical Research Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) M01RR01346 / Frederic C. Bartter General Clinical Research Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) M01RR02719 / Johns Hopkins Medical Institutions Bayview General Clinical Research Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) National Institute of Nursing Research; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Nursing Research (NINR) VA Puget Sound Health Care System Medical Research Service, Department of Veterans Affairs M01RR00051 / University of Colorado Health Sciences Center General Clinical Research Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) M01RR0021140 / University of Tennessee at Memphis General Clinical Research Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) P30 DK48520 / Clinical Nutrition Research Unit National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) M01RR000056 44 / University of Pittsburgh General Clinical Research Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) U01DK056990; U01DK057131; U01DK056992; U01DK057182; U01DK057151; P30DK026687; P30DK046204; U01DK057177; U01DK057008; P30DK017047; U01DK057178; R01DK090043; P30DK048520; U01DK057078; U01DK057135; U01DK057136; U01DK057149; U01DK057219; U01DK057171; U01DK057154; U01DK057002 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) DK57136; DK57149; DK56990; DK57177; DK57171; DK57151; DK57182; DK57131; DK57002; DK57078; DK57154; DK57178; DK57219; DK57008; DK57135; DK56992 / Department of Health and Human Services from the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA National Institutes of Health Office of Research on Women's Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS); NIH Office of Research on Women's Health (ORWH) M01RR000051; UL1RR025758; M01RR001066; M01RR000056; M01RR001346; M01RR002719 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Counseling and Family Therapy; Drexel University
- Web of Science ID
- WOS:000364497100004
- Scopus ID
- 2-s2.0-84947490643
- Other Identifier
- 991020099629704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Psychiatry
- Psychology
- Psychology, Multidisciplinary