Journal article
Genetic Regulation of Long-Term Nonprogression in E-55+ Murine Leukemia Virus Infection in Mice
Journal of virology, v 73(11), pp 9232-9236
Nov 1999
PMID: 10516031
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Certain inbred mouse strains display progression to lymphoma development after infection with E-55+ murine leukemia virus (E-55+ MuLV), while others demonstrate long-term nonprogression. This difference in disease progression occurs despite the fact that E-55+ MuLV causes persistent infection in both immunocompetent BALB/c–
H-2
k
(BALB.K) progressor (P) and C57BL/10–
H-2
k
(B10.BR) long-term nonprogressor (LTNP) mice. In contrast to immunocompetent mice, immunosuppressed mice from both P and LTNP strains develop lymphomas about 2 months after infection, indicating that the LTNP phenotype is determined by the immune response of the infected mouse. In this study, we used bone marrow chimeras to demonstrate that the LTNP phenotype is associated with the genotype of donor bone marrow and not the recipient microenvironment. In addition, we have mapped a genetic locus that may be responsible for the LTNP trait. Microsatellite-based linkage analysis demonstrated that a non-major histocompatibility complex gene on chromosome 15 regulates long-term survival and is located in the same region as the
Rfv3
gene.
Rfv3
is involved in recovery from Friend virus-induced leukemia and has been demonstrated to regulate neutralizing virus antibody titers. In our studies, however, both P and LTNP strains produce similar titers of neutralizing and cytotoxic anti-E-55+ MuLV. Therefore, while it is possible that
Rfv3
influences the course of E-55+ MuLV infection, it is more likely that the LTNP phenotype in E-55+ MuLV-infected mice is regulated by a different, closely linked gene.
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Details
- Title
- Genetic Regulation of Long-Term Nonprogression in E-55+ Murine Leukemia Virus Infection in Mice
- Creators
- Vily Panoutsakopoulou - Department of Pathology and Department of Microbiology and Immunology, MCP Hahnemann School of Medicine, Philadelphia, Pennsylvania 19102Kathryn Hunter - Department of Pathology and Department of Microbiology and Immunology, MCP Hahnemann School of Medicine, Philadelphia, Pennsylvania 19102Thomas G Sieck - Department of Pathology and Department of Microbiology and Immunology, MCP Hahnemann School of Medicine, Philadelphia, Pennsylvania 19102Elizabeth P Blankenhorn - Department of Pathology and Department of Microbiology and Immunology, MCP Hahnemann School of Medicine, Philadelphia, Pennsylvania 19102Kenneth J Blank - Department of Pathology and Department of Microbiology and Immunology, MCP Hahnemann School of Medicine, Philadelphia, Pennsylvania 19102
- Publication Details
- Journal of virology, v 73(11), pp 9232-9236
- Publisher
- American Society for Microbiology
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000083071200036
- Scopus ID
- 2-s2.0-0032867491
- Other Identifier
- 991014878316604721
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- Web of Science research areas
- Virology