Journal article
Genetic analysis of a mammalian wound-healing trait
Proceedings of the National Academy of Sciences - PNAS, v 95(20), pp 11792-11797
29 Sep 1998
PMID: 9751744
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Wound healing of mammalian tissue is an essential process in the
maintenance of body integrity. The general mechanism of wound healing
usually studied in adult mammals is repair, in contrast to the
regeneration seen in more primitive vertebrates. We recently have
discovered that MRL/MpJ mice, unlike all other strains of mice
tested, undergo rapid and complete wound closure that resembles
regeneration. Specifically, through-and-through surgical ear hole
wounds close without scarring in <4 weeks with normal gross and
microanatomic architecture, including chondrogenesis. We also
demonstrated that this healing is a heritable trait in inbred mice. In
this study, we present results pertaining to its genetic control in
progeny segregating for this phenotype. To identify the genetic loci
that control the wound closure process, a genome-wide scan was
performed on (MRL/MpJ-
Fas
lpr
×
C57BL/6)F2 and backcross populations. In the primary screens of these
populations, quantitative trait loci that control the extent of wound
closure were detected on chromosomes 8, 12, and 15 and at two separate
locations on chromosome 13. Evidence of further genetic control of
healing was found on chromosome 7. All alleles that contribute to full
wound closure are derived from the
MRL/MpJ-
Fas
lpr
parent except for the
quantitative trait locus on chromosome 8, which is derived from
C57BL/6.
Metrics
Details
- Title
- Genetic analysis of a mammalian wound-healing trait
- Creators
- Beth Ann McBrearty - Wistar Institute, 3400 Spruce Street, Philadelphia, PA 19104; andLise Desquenne Clark - Wistar Institute, 3400 Spruce Street, Philadelphia, PA 19104; andXiang-Ming Zhang - Wistar Institute, 3400 Spruce Street, Philadelphia, PA 19104; andElizabeth P Blankenhorn - Wistar Institute, 3400 Spruce Street, Philadelphia, PA 19104; andEllen Heber-Katz - Wistar Institute, 3400 Spruce Street, Philadelphia, PA 19104; and
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, v 95(20), pp 11792-11797
- Publisher
- National Academy of Sciences
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000076222200053
- Scopus ID
- 2-s2.0-0032578399
- Other Identifier
- 991014878192504721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Genetics & Heredity