Journal article
Genetic analysis of disease subtypes and sexual dimorphisms in mouse experimental allergic encephalomyelitis (EAE): relapsing/remitting and monophasic remitting/nonrelapsing EAE are immunogenetically distinct
The Journal of immunology (1950), v 162(5), pp 3096-3102
01 Mar 1999
PMID: 10072563
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Experimental allergic encephalomyelitis (EAE) is the principal animal model of multiple sclerosis (MS), the major inflammatory disease of the central nervous system. Murine EAE is generally either an acute monophasic or relapsing disease. Because the clinical spectrum of MS is more diverse, the limited range of disease subtypes observed in EAE has raised concern regarding its relevance as a model for MS. During the generation of a large F2 mapping population between the EAE-susceptible SJL/J and EAE-resistant B10.S/DvTe inbred lines, we identified four distinct subtypes of murine EAE resembling clinical subtypes seen in MS. We observed acute progressive, chronic/nonremitting, remitting/relapsing, and monophasic remitting/nonrelapsing EAE. An additional subtype, benign EAE, was identified after histologic examination revealed that some mice had inflammatory infiltrates of the central nervous system, but did not show clinical signs of EAE. Genome exclusion mapping was performed to identify the loci controlling susceptibility to each disease subtype. We report three novel EAE-modifying loci on chromosomes 16, 7, and 13 (eae11-13, respectively). Additionally, unique loci with gender-specific effects govern susceptibility to remitting/relapsing (eae12) and monophasic remitting/nonrelapsing (eae7 and 13) EAE.
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Details
- Title
- Genetic analysis of disease subtypes and sexual dimorphisms in mouse experimental allergic encephalomyelitis (EAE): relapsing/remitting and monophasic remitting/nonrelapsing EAE are immunogenetically distinct
- Creators
- R J Butterfield - Department of Veterinary Pathobiology, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USAE P BlankenhornR J RoperJ F ZacharyR W DoergeJ SudweeksJ RoseC Teuscher
- Publication Details
- The Journal of immunology (1950), v 162(5), pp 3096-3102
- Publisher
- United States
- Grant note
- AI41747 / NIAID NIH HHS NS36526 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000078699000083
- Scopus ID
- 2-s2.0-0033104698
- Other Identifier
- 991014877941104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology