Journal article
Genetic association of FKBP5 with PTSD in US service members deployed to Iraq and Afghanistan
Journal of psychiatric research, v 122, pp 48-53
Mar 2020
PMID: 31927265
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Post-traumatic stress disorder (PTSD) is a debilitating mental disorder with a prevalence of more than 7% in the US population and 12% in the military. An interaction of childhood trauma with FKBP5 (a glucocorticoid-regulated immunophilin) has been reported to be associated with PTSD in the general population. However, there are few reports on the association of FKBP5 with PTSD, particularly in important high-risk population such as the military. Here, we examined the association between four single-nucleotide polymorphisms (SNPs; rs3800373, rs9296158, rs1360780, rs9470080) covering the FKBP5 gene and probable PTSD in US service members deployed to Iraq and Afghanistan, a high-risk military population (n = 3890) (Hines et al., 2014). We found that probable PTSD subjects were significantly more likely to carry the A-allele of rs3800373, G-allele of rs9296158, C-allele of rs1360780, and C-allele of rs9470080. Furthermore, the four SNPs were in one block of strong pairwise linkage disequilibrium (r = 0.91–0.96). Within the block there were two major haplotypes of CATT and AGCC (rs3800373-rs9296158-rs1360780-rs9470080) that account for 99% of haplotype diversity. The distribution of the AGCC haplotype was significantly higher in probable PTSD subjects compared to non-PTSD (p<.05). The diplotype-based analysis indicated that the AGCC carriers tended to be probable PTSD. In this study, we demonstrated the association between FKBP5 and probable PTSD in US service members deployed to Iraq and Afghanistan, indicating that FKBP5 might be a risk factor for PTSD.
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Details
- Title
- Genetic association of FKBP5 with PTSD in US service members deployed to Iraq and Afghanistan
- Creators
- Lei Zhang - Uniformed Services University of the Health SciencesXian-Zhang Hu - Uniformed Services University of the Health SciencesTianzheng Yu - Uniformed Services University of the Health SciencesZe Chen - Uniformed Services University of the Health SciencesJacob Dohl - Uniformed Services University of the Health SciencesXiaoxia Li - Uniformed Services University of the Health SciencesDavid M. Benedek - Uniformed Services University of the Health SciencesCarol S. Fullerton - Uniformed Services University of the Health SciencesGary Wynn - Uniformed Services University of the Health SciencesJames E. Barrett - Drexel UniversityMian Li - Washington DC VA Medical CenterDale W. Russell - Center for the Study of Traumatic Stress, Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USARobert J. Ursano - Uniformed Services University of the Health SciencesBiomarker team
- Publication Details
- Journal of psychiatric research, v 122, pp 48-53
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:000515429000008
- Scopus ID
- 2-s2.0-85077433939
- Other Identifier
- 991019168416504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Psychiatry