Journal article
Genetic basis for skin youthfulness
Clinics in dermatology, v 37(4)
01 Jul 2019
PMID: 31345318
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Aging skin is a consequence of both intrinsic factors, including genetics, and extrinsic factors, including environmental exposures such as ultraviolet (UV) radiation and smoking. This contribution focuses on intrinsic factors that promote aging skin. Specifically, in this contribution we review the literature describing how single nucleotide polymorphisms, epigenetic changes, variable gene expression, microRNA, and mitochondrial depletion relate to skin aging. Investigations studying intrinsic factors associated with skin aging are important as they promote a better understanding of the underlying pathophysiology of aging skin. This contribution also describes potential avenues for future genetic research in skin aging. Molecular mechanisms that may be therapeutically intervened upon are of particular interest given the cultural value placed on youthful appearing skin. Future research efforts will hopefully reveal a means upon which to intercede on the skin aging process.
Metrics
Details
- Title
- Genetic basis for skin youthfulness
- Creators
- Kelsey S. Flood - College Station Medical CenterNeil A. Houston - University of Colorado DenverKevin T. Savage - Drexel UniversityAlexa B. Kimball - College Station Medical Center
- Publication Details
- Clinics in dermatology, v 37(4)
- Publisher
- Elsevier
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000478702800004
- Scopus ID
- 2-s2.0-85066506678
- Other Identifier
- 991021860808004721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Dermatology