Journal article
Genetic control of rat T-cell response to Staphylococcus aureus enterotoxins (SE)
Immunology, v 74(3), pp 484-489
Nov 1991
PMID: 1769696
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Abstract
Rat T cells, like those of mouse and human origin, respond strongly to superantigens (SAg) derived from Staphylococcus aureus enterotoxins A and B (SEA, SEB). Lewis and ACI are high responders, whereas Brown Norway (BN) is a low responder. Congenic and back-cross rat studies indicate that the degree of responsiveness is controlled by at least one non-MHC gene. The action of these genes may reside in the antigen-presenting cells (APC), since both Sephadex G10 non-adherent BN spleen cells and purified BN T cells in the presence of Lewis APC can respond well to SE. Responses to concanavalin A (Con A) and SEA generally segregate together in back-cross rats. Surprisingly, the degree of responsiveness to Con A and SEA is not correlated with the susceptibility to experimental allergic encephalomyelitis (EAE) either in independently derived inbred rat strains or in (Lewis x BN) x BN back-cross rats.
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Details
- Title
- Genetic control of rat T-cell response to Staphylococcus aureus enterotoxins (SE)
- Creators
- Y Fu - Department of Microbiology and Immunology, Hahnemann University, Philadelphia, PA 19102P A VillasE P Blankenhorn
- Publication Details
- Immunology, v 74(3), pp 484-489
- Grant note
- NS25519 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:A1991GP91300019
- Scopus ID
- 2-s2.0-0025931943
- Other Identifier
- 991019183920104721
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- Web of Science research areas
- Immunology