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Journal article
Genetic liability for gastrointestinal inflammation disorders and association with gastrointestinal symptoms in children with and without autism
American journal of medical genetics. Part B, Neuropsychiatric genetics, v 195(1), e32952
Jan 2024
PMID: 37455590
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Children with autism spectrum disorder (ASD) have a greater prevalence of gastrointestinal (GI) symptoms than children without ASD. We tested whether polygenic scores for each of three GI disorders (ulcerative colitis, inflammatory bowel disease, and Crohn's disease) were related to GI symptoms in children with and without ASD. Using genotyping data (564 ASD cases and 715 controls) and external genome-wide association study summary statistics, we computed GI polygenic scores for ulcerative colitis (UC-PGS), inflammatory bowel disease (IDB-PGS), and Crohn's disease (CD-PGS). Multivariable logistic regression models, adjusted for genetic ancestry, were used to estimate associations between each GI-PGS and (1) ASD case-control status, and (2) specific GI symptoms in neurotypical children and separately in ASD children. In children without ASD, polygenic scores for ulcerative colitis were significantly associated with experiencing any GI symptom (adjusted odds ratio (aOR) = 1.36, 95% confidence interval (CI) = 1.03-1.81, p = 0.03) and diarrhea specifically (aOR = 5.35, 95% CI = 1.77-26.20, p = 0.01). Among children without ASD, IBD-PGS, and Crohn's PGS were significantly associated with diarrhea (aOR = 3.55, 95% CI = 1.25-12.34, p = 0.02) and loose stools alternating with constipation (aOR = 2.57, 95% CI = 1.13-6.55, p = 0.03), respectively. However, the three PGS were not associated with GI symptoms in the ASD case group. Furthermore, polygenic scores for ulcerative colitis significantly interacted with ASD status on presentation of any GI symptom within a European ancestry subset (aOR = 0.42, 95% CI = 0.19-0.88, p = 0.02). Genetic risk factors for some GI symptoms differ between children with and without ASD. Furthermore, our finding that increased genetic risks for GI inflammatory disorders are associated with GI symptoms in children without ASD informs future work on the early detection of GI disorders.
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Details
- Title
- Genetic liability for gastrointestinal inflammation disorders and association with gastrointestinal symptoms in children with and without autism
- Creators
- Valerie Morrill - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USAKelly Benke - Center for Autism and Related DisordersJohn Brinton - Children's Hospital ColoradoGnakub N Soke - Colorado School of Public HealthLaura A Schieve - National Center on Birth Defects and Developmental DisabilitiesVictoria Fields - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USAHomayoon Farzadegan - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USACalliope Holingue - Johns Hopkins UniversityCraig J Newschaffer - College of Health and Human Development, Pennsylvania State University, Pennsylvania, USAAnn M Reynolds - University of Colorado DenverM Daniele Fallin - Johns Hopkins UniversityChristine Ladd-Acosta - Johns Hopkins University
- Publication Details
- American journal of medical genetics. Part B, Neuropsychiatric genetics, v 195(1), e32952
- Publisher
- Wiley
- Grant note
- U01 DD000498 / NCBDD CDC HHS NIEHS NIH HHS CC999999 / Intramural CDC HHS CDC HHS U10 DD000180 / NCBDD CDC HHS U10 DD000184 / NCBDD CDC HHS U01 DD001297 / NCBDD CDC HHS P50 HD103538 / NICHD NIH HHS U10 DD000901 / NCBDD CDC HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:001030919200001
- Scopus ID
- 2-s2.0-85165325726
- Other Identifier
- 991021861183504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Genetics & Heredity
- Psychiatry