Journal article
Genetic loci that regulate healing and regeneration in LG/J and SM/J mice
Mammalian genome, v 20(11), pp 720-733
2009
PMID: 19760323
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
MRL mice display unusual healing properties. When MRL ear pinnae are hole punched, the holes close completely without scarring, with re-growth of cartilage, and reappearance of both hair follicles and sebaceous glands. Studies using (MRL/
lpr
x C57BL/6)F
2
and backcross mice first showed that this phenomenon was genetically determined and that multiple loci contributed to this quantitative trait. The
lpr
mutation itself, however, was not one of them. In the present study, we examined the genetic basis of healing in the Large (LG/J) mouse strain, a parent of the MRL mouse and a strain that shows the same healing phenotype. LG/J mice were crossed with Small (SM/J) mice and the F
2
population was scored for healing and their genotypes determined at >200 polymorphic markers. As we previously observed for MRL and (MRL x B6)F
2
mice, the wound healing phenotype was sexually dimorphic with female mice healing more quickly and more completely than male mice. We found quantitative trait loci (QTL) on chromosomes (chr) 9, 10, 11, and 15. The heal QTL on chrs 11 and 15 were linked to differential healing primarily in male animals, whereas QTL on chrs 9 and 10 were not sexually dimorphic. A comparison of loci identified in previous crosses with those in the present report using LG/J x SM/J showed that loci on chrs 9, 11 and 15 co-localized with those seen in previous MRL crosses, whereas the locus on chr 10 was not seen before and was is contributed by SM/J.
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Details
- Title
- Genetic loci that regulate healing and regeneration in LG/J and SM/J mice
- Creators
- Elizabeth P Blankenhorn - Department of Microbiology and Immunology, Drexel University, College of Medicine, 2900 Queen Lane, Philadelphia PA 19129Gregory Bryan - Department of Microbiology and Immunology, Drexel University, College of Medicine, 2900 Queen Lane, Philadelphia PA 19129Andrew V Kossenkov - The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania, 19104, USALise Desquenne Clark - The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania, 19104, USAXiang-Ming Zhang - The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania, 19104, USACelia Chang - The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania, 19104, USAWenhwai Horng - The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania, 19104, USAL. Susan Pletscher - Department of Anatomy & Neurobiology, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110James M Cheverud - Department of Anatomy & Neurobiology, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110Louise Showe - The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania, 19104, USAEllen Heber-Katz - The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania, 19104, USA
- Publication Details
- Mammalian genome, v 20(11), pp 720-733
- Publisher
- Springer Nature
- Grant note
- S10 RR024693 || RR / National Center for Research Resources : NCRR R01 GM073226 || GM / National Institute of General Medical Sciences : NIGMS P30 CA010815 || CA / National Cancer Institute : NCI
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000272905200002
- Scopus ID
- 2-s2.0-73549102683
- Other Identifier
- 991014877893804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biotechnology & Applied Microbiology
- Genetics & Heredity