Journal article
Genetic polymorphisms in MMP 2, 3, 7, and 9 genes and the susceptibility and clinical outcome of cervical cancer in a Chinese Han population
Tumor biology, v 37(4), pp 4883-4888
01 Apr 2016
PMID: 26526578
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Matrix metalloproteases (MMPs) are proteolytic enzymes that contribute to all stages of tumor progression, including the invasion and metastasis. However, there are no data about the role of MMP polymorphism in the development of cervical cancer. A hospital-based case-control study was conducted in 230 patients with cervical cancer and 230 healthy controls to investigate the possible association between the MMP2 rs243865, MMP3 rs3025058, MMP7 rs11568818, and MMP9 rs3918242 polymorphisms, respectively, and the risk of cervical cancer. Our results suggested that the MMP2 rs243865-1306 C/T was significantly associated with an increased risk of cervical cancer (CT vs. CC, OR = 1.46; 95 % CI 1.18-3.55; P = 0.032; TT vs. CC, OR = 1.72; 95 % CI 1.28-4.02; P = 0.031; CT + TT vs. CC, OR = 1.43; 95 % CI 1.21-3.44; P = 0.029). Similarly, the MMP7 rs11568818-181A/G genotypes can also elevate the risk of cervical cancer in all genetic models. However, the genotype and allele frequencies of MMP3 rs3025058 and MMP9 rs3918242 polymorphisms in cervical cancer patients were not significantly different from controls. Further analysis showed MMP2 rs243865 and MMP7 rs11568818 genotypes were associated with advanced tumor stages of cervical cancer patients. More interestingly, the MMP2 rs243865 and MMP7 rs11568818 genotype was statistically significantly associated with a poor survival in cervical cancer patients. Our results showed that the MMP2 rs243865 and MMP7 rs11568818 genotypes e were associated with increased susceptibility and development of cervical cancer in Chinese Han population.
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Details
- Title
- Genetic polymorphisms in MMP 2, 3, 7, and 9 genes and the susceptibility and clinical outcome of cervical cancer in a Chinese Han population
- Creators
- Beibei Xie - Qilu Hospital of Shandong UniversityZhen Zhang - Linyi People's HospitalHui Wang - Linyi People's HospitalZhaojie Chen - Linyi People's HospitalYongsheng Wang - Linyi People's HospitalHuazheng Liang - Neuroscience Research AustraliaGaoyuan Yang - Linyi People's HospitalXingsheng Yang - Qilu Hospital of Shandong UniversityHaiyan Zhang - Linyi People's Hospital
- Publication Details
- Tumor biology, v 37(4), pp 4883-4888
- Publisher
- Springer Nature
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000374904500070
- Scopus ID
- 2-s2.0-84946125470
- Other Identifier
- 991019320611904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology