Journal article
Genetic variation and HIV-associated neurologic disease
Advances in virus research, v 87, pp 183-240
2013
PMID: 23809924
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
HIV-associated neurologic disease continues to be a significant complication in the era of highly active antiretroviral therapy. A substantial subset of the HIV-infected population shows impaired neuropsychological performance as a result of HIV-mediated neuroinflammation and eventual central nervous system (CNS) injury. CNS compartmentalization of HIV, coupled with the evolution of genetically isolated populations in the CNS, is responsible for poor prognosis in patients with AIDS, warranting further investigation and possible additions to the current therapeutic strategy. This chapter reviews key advances in the field of neuropathogenesis and studies that have highlighted how molecular diversity within the HIV genome may impact HIV-associated neurologic disease. We also discuss the possible functional implications of genetic variation within the viral promoter and possibly other regions of the viral genome, especially in the cells of monocyte-macrophage lineage, which are arguably key cellular players in HIV-associated CNS disease.
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Details
- Title
- Genetic variation and HIV-associated neurologic disease
- Creators
- Satinder Dahiya - Department of Microbiology and Immunology, Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, USABryan P Irish - Department of Microbiology and Immunology, Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, USAMichael R Nonnemacher - Department of Microbiology and Immunology, Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, USABrian Wigdahl - Department of Microbiology and Immunology, Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
- Publication Details
- Advances in virus research, v 87, pp 183-240
- Publisher
- Elsevier; United States
- Grant note
- R01 DA019807 / NIDA NIH HHS DA19807 / NIDA NIH HHS NS32092 / NINDS NIH HHS R01 NS032092 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000322845900006
- Scopus ID
- 2-s2.0-84879584023
- Other Identifier
- 991014878120004721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Virology