Journal article
Genetic variation in the sex hormone metabolic pathway and endometriosis risk: an evaluation of candidate genes
Fertility and sterility, v 96(6), pp 1401-1406
2011
PMID: 21958689
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To evaluate the relationship between common genetic variation in genes involved in the biosynthesis and signaling of estrogen and progesterone and endometriosis risk.
Genetic polymorphism analysis.
Population-based case-control study conducted in Group Health Cooperative enrollees in western Washington.
Women with newly diagnosed, surgically confirmed endometriosis between 1996 and 2001 (n = 256) and age- and reference year–matched female control subjects without a history of endometriosis (n = 567).
None.
We evaluated the relationship between common genetic variation and endometriosis risk, using gene-based tests and single-variant analysis of genetic polymorphisms in
ESR1,
ESR2,
PGR,
CYP17A1,
CYP19A1,
HSD17B1,
HSD17B2,
CYP1A1,
CYP1A2,
COMT, and
GSTM1.
The most consistent gene-based association with endometriosis risk was for
CYP19A1. We did not find evidence for consistent significant associations between previously reported candidate SNPs in sex hormone–related genes and endometriosis risk.
In summary, we report increased endometriosis risk with
CYP19A1 gene-based tests; replication of the association between endometriosis and this gene or gene region is necessary in a larger study population.
Metrics
Details
- Title
- Genetic variation in the sex hormone metabolic pathway and endometriosis risk: an evaluation of candidate genes
- Creators
- Britton Trabert - Fred Hutch Cancer CenterStephen M. Schwartz - Fred Hutch Cancer CenterUlrike Peters - Fred Hutch Cancer CenterAnneclaire J. De Roos - Fred Hutch Cancer CenterChu Chen - Fred Hutch Cancer CenterDelia Scholes - Group Health CooperativeVictoria L. Holt - Fred Hutch Cancer Center
- Publication Details
- Fertility and sterility, v 96(6), pp 1401-1406
- Publisher
- Elsevier
- Grant note
- National Institutes of Health P30ES007033 / Royalty Research Fund and the Center for Ecogenetics and Environmental Health R01HD033792; T32HD052462 / Eunice Kennedy Shriver National Institute of Child Health and Human Services
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000298119700031
- Scopus ID
- 2-s2.0-82455212161
- Other Identifier
- 991020099209304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Obstetrics & Gynecology
- Reproductive Biology